影响多囊卵巢综合征不孕患者治疗依从性的相关因素分析

目的 调查多囊卵巢综合征（PCOS）不孕患者治疗依从性的相关影响因素,为临床治疗、专科咨询及健康教育提供依据.方法 借鉴综合Morisky问卷及PCOS防治原则设计调查问卷,对白2009年3月到2010年9月到本院生殖中心门诊就诊的PCOS不孕患者共128例进行问卷调查,并对结果进行logistic回归分析.结果 除去不完整及随访脱落病例,最终120例纳入统计范围.经logistic回归分析显示纳入分析的患者中仅34.2%（41/120）依从性好,与PCOS不孕患者治疗依从性相关的因素有体重指数（OR=2.426,95% CI=1.428～4.121）、结婚时间（OR=0.398,95% CI=0.225～0.704）、担心药物不良反应（OR=0.216,95% CI=0.067～0.694）（P＜0.05）.结论 肥胖、结婚时间短及担心药物不良反应的PCOS不孕患者治疗依从性较低,临床上应加强对这部分人群的宣传及干预以提高PCOS依从性.

Correlates of treatment compliance in infertile patients with polycystic ovary syndrome

Objective To investigate factors that correlated to compliance of treatment in infertile patients with polycystic ovary syndrome (PCOS) to provide basis for clinical treatment, specialist consultation and health education. Methods Compliance was assessed by a questionnaire designed by reference to Morisky-Green test and therapeutic principles for PCOS. Interviews were performed in 128 infertile patients with PCOS in Renmin Hospital of Wuhan University, Wuhan, Hubei in China during March 2009 to September 2010. Data were analyzed with logistic regression. Results Logistic regression analysis revealed that a total of 41 (34.2% ) of 120 participants investigated showed good compliance. Factors that might significantly (P ＜ 0.05 ) correlate compliance of treatment included body mass index (BMI) of the patients ( OR = 2.426, 95% CI = 1.428 - 4.121 ), length of their marriage ( OR = 0.398, 95% CI =0.225 - 0.704) and their concerns for adverse drug reactions ( OR= 0.216, 95% CI = 0.067 - 0.694).Conclusions Patients with obesity, shorter length of marriage and concerns for adverse drug reactions show lower compliance. Publicity and intervention to those patients should be strengthened in clinics to improve their treatment compliance in patients with PCOS.