吸烟与中国人群肺结核发病的Meta分析

目的 研究吸烟与中国人群肺结核发病的关系.方法 检索的中文数据库包括万方、维普、中国知网(CNKI),英文数据库PubMed,利用Meta分析的方法对2016年4月前国内外关于吸烟与中国人群肺结核发病的研究文献进行分析.结果 共纳入15个研究,排除其中1个低质量研究后,其余研究无统计学异质性,合并后OR值为1.71,95％CI:1.54～1.90.其中两个研究观察了吸烟量与结核发病的关系,但存在异质性,无法进一步合并OR值进行分析.所有研究均未对性别进行亚组分析.结论 中国人吸烟者患结核病的危险性是不吸烟者的1.71倍,吸烟会增加肺结核发病风险.

A meta-analysis on smoking and pulmonary tuberculosis incidence in Chinese people

Objective To study the relationship between smoking and the incidence of pulmonary tuberculosis(TB) in Chinese people.Methods The Pubmed database and three Chinese databases such as Wanfang Data,Veipu data(VIP) and China national knowledge infrastructure database (CNKI) were retrieved.The literatures on the relationship between smoking and pulmonary TB incidence in Chinese people published before April 2016 were analyzed.Results Fifteen studies were included,after excluding 1 low quality study,the rest had no statistical heterogeneity.The merged odd ratio (OR) was 1.71,95 ％ confidence interval (CI) 1.51-1.90.Two studies observed the relationship between the amount of cigarettes and TB pathogenesis,but there was heterogeneity and could not be further merged the OR value for conducting analysis.No subgroup analysis of gender was performed in all studies.Conclusion The risk suffering from pulmonary TB in Chinese smokers is 1.71 fold of non-smokers,and smoking increases the risk of pulmonary TB onset.