| 依达拉奉对百草枯中毒致急性肺损伤预防及治疗作用研究 |
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| 引用本文： | 尤再春,史忠,高全杰,周坤,李霞,卢玉宝.依达拉奉对百草枯中毒致急性肺损伤预防及治疗作用研究[J].重庆医学,2008,37(22):2517-2519. |
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| 作者姓名： | 尤再春 史忠 高全杰 周坤 李霞 卢玉宝 |
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| 作者单位： | 第三军医大学新桥医院急救部,重庆,400037;第三军医大学新桥医院急救部,重庆,400037;第三军医大学新桥医院急救部,重庆,400037;第三军医大学新桥医院急救部,重庆,400037;第三军医大学新桥医院急救部,重庆,400037;第三军医大学新桥医院急救部,重庆,400037 |
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| 摘 要： | 目的 探讨依达拉奉注射液对百草枯中毒致急性肺损伤的预防及治疗作用.方法 将2006年2月至2008年2月收治的30例百草枯中毒患者随机分为依达拉奉治疗组(A组,16例)和对照组(B组,14例).检测血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、谷光甘肽过氧化物酶(GSH-px)含量来评定氧自由基水平及自由基清除系统活性.结果 A组与B组比较,血浆中MDA含量下降,SOD和GSH-px活力升高(P<0.01).结论 依达拉奉可以预防及治疗百革枯中毒引起的急性肺损伤.
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| 关 键 词： | 依达拉奉 百草枯中毒 急性肺损伤 |
The study of preventive and therapeutic effects of edaravone against paraquat-induced acute lung injury |
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| YOU Zai-chun,SHI Zhong,GAO Quan-jie,et al..The study of preventive and therapeutic effects of edaravone against paraquat-induced acute lung injury[J].Chongqing Medical Journal,2008,37(22):2517-2519. |
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| Authors: | YOU Zai-chun SHI Zhong GAO Quan-jie |
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| Institution: | YOU Zai-chun,SHI Zhong,GAO Quan-jie,et al.(Emergency Department,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China) |
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| Abstract: | Objective To study the preventive and therapeutic effects of edaravone against paraquat-induced acute lung injury.Methods Thirty paraquat poisioning patients between Feb 2003 and Feb 2008 in our hospital were divided into A group(n=16,treated with edaravone)and B group(n=14,treated with conventional therapy).The plasma level of malonaldehyde(MDA),superoxide dismutase(SOD),and glutathione peroxidase(GSH-px)were measured.Results Comparing with those of B group,MDA level decreased and SOD,GSH-px increased sign... |
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| Keywords: | edaravone paraquat acute lung injury |
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