| 氨利酮诱发V79细胞HGPRT位点突变研究 |
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| 引用本文： | 周谷,刘玉清.氨利酮诱发V79细胞HGPRT位点突变研究[J].重庆医学,1996,25(3):129-130. |
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| 作者姓名： | 周谷 刘玉清 |
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| 作者单位： | 华西医科大学卫生毒理研究室!610041 |
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| 摘 要： | 本文观察了国产心血管疾病新药氨利酮在Ｖ７９细胞ＨＧＰＲＴ位点正向突变试验系统中的诱变作用。结果表明：氨利酮在Ｓ９情况下，各浓度组突变体频率与对照组相比均未达到ＭＦ≥３ＳＭＦ的标准，也无剂量反应关系；但相同浓度在＋Ｓ９情况下，除高浓度组外，蓁三组ＭＦ随浓度增加而升高，且次高浓度组ＭＦ是对照组的３．８倍，故在本试验条件下氨利酮是需活化的诱变剂。
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| 关 键 词： | 氨利酮 HGPRT位点 V79细胞 致突变性 |
THE INDUCTION OF 6-THIOGUANINE-RESISTANT MUTANTSV79 CHINESE HAMSTER CELLS BY AMRINONE |
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| Zhou Gu,Liu Yuqing,Pang Dingguo,zhang XiaolingResearch Laboratory of Hygienic Toxicology,West ChineUniversity of Medical Sciences,Chendu,Sichuan.THE INDUCTION OF 6-THIOGUANINE-RESISTANT MUTANTSV79 CHINESE HAMSTER CELLS BY AMRINONE[J].Chongqing Medical Journal,1996,25(3):129-130. |
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| Authors: | Zhou Gu Liu Yuqing Pang Dingguo zhang XiaolingResearch Laboratory of Hygienic Toxicology West ChineUniversity of Medical Sciences Chendu Sichuan |
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| Institution: | Zhou Gu,Liu Yuqing,Pang Dingguo,zhang XiaolingResearch Laboratory of Hygienic Toxicology,West ChineUniversity of Medical Sciences,Chendu,Sichuan,610041 |
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| Abstract: | Inducibility of 6-thioguanine-resistant mutants by a new medicine-amrinone was investigated. In the absence of S9. no mutagenic effect was found. In the presence of S9, mutant frequencies were increased with am-rinone concentration from 10uM to 100uM, but decreased at 200uM. At 100uM mutant frequency was increased more than three-fold over spontaneous mutant values. Thus it was suggested that amrinone can induce mammalian cells gene mutation. |
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| Keywords: | amrinone V79 Chinese hamster cell 6-thioguanine-resistant mutant |
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