n-HA/PA66复合生物活性支撑材料在重建椎体结构中的初步临床应用

目的 探讨自行研制的纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合生物活性支撑材料在恢复椎体结构和高度中的作用.方法 从2003年12月～2005年5月行n-HA/PA66复合生物活性支撑材料移植重建脊柱前路手术后的椎体缺损共36例.应用病种:椎体爆裂骨折32例、原发椎间隙感染2例、椎体肿瘤2例.结果 随访6～21个月(平均8个月),影像学资料显示植入体3～4个月与上下相邻椎体愈合、重建的椎体高度没有降低、术前神经损伤不同程度恢复.结论 纳米羟基类磷灰石/聚酰胺66(n-HA/PA66)复合生物活性支撑材料可有效恢复椎体高度和结构,并能与椎体愈合,达到有效重建椎体结构的作用,可以临床推广使用.

Initial clinical research of biomimetic and supportive n-HA/PA66 composites for structural reconstruction of vertebral body in spine

Objective To study the clinical effects of the biomimetic and supportive n-HA/PA66 composites for the structural reconstruction and height restoring of vertebral body in the thoracolumbar spine. Methods Thirty-six patients received operation to reconstruct the spinal vertebral structure with the biomimetic and supportive n-HA/PA66 composites from anterior approach because of the vertebral deficit. There were 32 cases of vertebral bursting fracture, 2 cases of spontaneous discitis and 2 cases of vertebral tumor in this series. Results The period of follow-up lasted 8 months, ranging from 6 to 21 months. The implant was healed after 3 or 4 months postoperatively. The reconstructive height of vertebra was maintained. The neural symptoms were improved in different degree. Conclusion The biomimetic and supportive n-HA/PA66 composites can effectively restore the height and structure of vertebra, and can be fused with vertebral body to reconstruct spinal structural stability effectively. And they can be extensively used in clinic.