| SUMO-1基因在肝癌中的表达及意义 |
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| 引用本文： | 郭武华,袁丽华,肖志华,张吉翔.SUMO-1基因在肝癌中的表达及意义[J].重庆医学,2009,38(24):3115-3117. |
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| 作者姓名： | 郭武华 袁丽华 肖志华 张吉翔 |
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| 作者单位： | 1. 南昌大学第二附属医院,肿瘤科,330006
2. 南昌大学第二附属医院,消化科,330006 |
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| 摘 要： | 目的 研究肝癌传代细胞、肝癌标本及癌旁肝组织中SUMO-1基因的表达及意义.方法 采用RT-PCR、Western blot方法在mRNA及蛋白水平检测肝癌传代细胞、肝癌标本及癌旁肝组织中SUMO-1基因的表达.结果在mRNA及蛋白水平,SUMO-1基因在肝癌传代细胞SMMC-7721、Hep3B、HepG2及肝癌标本中均明显高表达,而癌旁肝组织中SUMO-1基因明显低表达,肝癌组织和癌旁肝组织中SUMO-1表达差异有统计学意义(P<0.001).结论 SUMO-1基因在肝癌中高表达,SUMO-1可能为肝癌诊断和治疗中的一个靶点.
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| 关 键 词： | 基因表达 肝癌 |
Expression and clinical significance of SUMO-1 in hepatocellular carcinoma |
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| GUO Wu-hua,YUAN Li-hua,XIAO Zhi-hua,et al..Expression and clinical significance of SUMO-1 in hepatocellular carcinoma[J].Chongqing Medical Journal,2009,38(24):3115-3117. |
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| Authors: | GUO Wu-hua YUAN Li-hua XIAO Zhi-hua |
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| Institution: | GUO Wu-hua1,YUAN Li-hua2,XIAO Zhi-hua2,et al.(1.Department of Oncology,2.Department of Gastroenterology,Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330006,China) |
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| Abstract: | Objective To investigate the expression and clinical significance of SUMO-1 in SMMC-7721,HepG2,Hep3B,hepatocellular carcinomas(HCC) and liver tissues surrounding HCC.Methods The mRNA and protein of SUMO-1 in SMMC-7721,HepG2,Hep3B,HCCs and liver tissue surrounding HCCs were examined by means of RT-PCR and Western blot.Results The expression level of SUMO-1 mRNA and protein elevated significantly in SMMC-7721,HepG2,Hep3B and hepatocellular carcinoma tissues.Although the quantities of SUMO-1 mRNA and protein v... |
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| Keywords: | SUMO-1 |
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