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| 乳腺癌HER2基因表达阳性者17号染色体倍体性与HER2蛋白表达及临床预后因素的相关性分析 | |
| 引用本文： | 陈红,许建平,马小干,程应东,杨桦,孙建国,陈正堂.乳腺癌HER2基因表达阳性者17号染色体倍体性与HER2蛋白表达及临床预后因素的相关性分析[J].重庆医学,2009,38(7). |
| 作者姓名： | 陈红 许建平 马小干 程应东 杨桦 孙建国 陈正堂 |
| 作者单位： | 1. 第三军医大学新桥医院全军肿瘤研究所 2. 第三军医大学新桥医院病理科 3. 第三军医大学新桥医院普通外科,重庆,400037 |
| 摘 要： | 目的 分析乳腺癌HER2基因表达阳性者17号染色体倍体性与HER2蛋白表达以及临床预后因素的相关性,以探讨其临床意义.方法 应用FISH、IHC等方法研究34例HER2基因有扩增的乳腺癌病例,分析17号染色体倍体性与HER2蛋白表达、乳腺癌临床预后因素的关系.结果 HER2基因表达阳性者17号染色体的多体性表达者较二体性表达者有更高的HER2蛋白表达级别(P<0.05),有更多的乳腺癌的不良预后因素出现概率(P<0.05).结论 FISH作为乳腺癌HER2基因检测手段不仅准确率高,而且能定量17号染色体的倍体性,从而为综合判断疾病的预后提供更多的依据. |
| 关 键 词： | 乳腺癌 荧光原位杂交 免疫组织化学 基因 |
Polysomy 17 in breast cancer with HER2 gene amplification:its role in HER2 protein expression and clinical prognostic factors |
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| CHEN Hong,XU Jian-ping,MA Xiao-gan,et al..Polysomy 17 in breast cancer with HER2 gene amplification:its role in HER2 protein expression and clinical prognostic factors[J].Chongqing Medical Journal,2009,38(7). | |
| Authors: | CHEN Hong XU Jian-ping MA Xiao-gan |
| Institution: | CHEN Hong1,XU Jian-ping2,MA Xiao-gan3,et al.(1.Institute of Cancer Research,2.Department of Pathology,3.Department of General Surgery,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China) |
| Abstract: | Objective To investigate the clinical significance of the relationship between polysomy 17 in breast cancer with HER2 gene amplification and HER2 protein expression as well as clinical prognostic factors.Methods Ploid of 34 cases with HER2 gene amplification assessed by fluorescence in situ hybridization(FISH),HER2 protein expression assessed by immunohistochemistry(IHC) the ralationship between polysomy 17,HER2 protein expression and clinical prognostic factors were analysed.Results A statistical correlati... |
| Keywords: | HER2 |
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