67例血液透析治疗患者微炎症与心血管疾病的关系

目的：探讨血液透析治疗患者微炎症与心血管疾病的关系。方法以血清C反应蛋白（CRP）作为微炎症的标记物，通过67例血液透析治疗患者的临床资料分析微炎症与心血管疾病的关系。另设健康对照组20例。结果血液透析治疗患者CRP水平高于健康对照组（P＜0．05）。血液透析治疗患者按照血清CRP水平分为两组：CRP升高组和CRP正常组，两组患者在有无高血压、发现高血压时间、心血管疾病发生率、病死率等方面比较差异有统计学意义（P＜0．05）；CRP升高组血清清蛋白、前清蛋白、高密度脂蛋白胆固醇和血红蛋白低于CRP正常组（P＜0．05），低密度脂蛋白胆固醇高于CRP正常组（P＜0．05）；67例患者CRP水平与血清清蛋白（r＝－0．46，P＜0．05）、前清蛋白（r＝－0．37，P＜ 0．05）、高密度脂蛋白胆固醇（r＝－0．49，P＜0．05）均呈负相关，与低密度脂蛋白胆固醇（ r＝0．55，P＜0．05）呈正相关。结论微炎症状态是血液透析治疗患者心血管疾病的危险因素。

The relationship between microinflammation and cardiovascular diseases in hemodialysis patients

Objective To investigate the relationship between microinflammation and cardiovascular diseases in hemodialysis patients .Methods Serum C-reactive protein(CRP) as a marker of microinflammation ,the clinical datum on 67 hemodia-lysis pa-tients were studied for the relationship between microinflammation and cardiovascular diseases .And there were 20 cases in the nor-mal control group .Results Compared with the normal control group ,there was a high level of CRP in the patients(P<0 .05) .The patients were divided into 2 groups:the group with CRP high level and the group with CRP normal level .There were significant differences(P<0 .05) in with and without hypertension history ,the period of hypertension history ,the incidence of cardiovascular diseases and mortality between the two groups .The levels of serum albumin ,pre-albumin ,high density lipoprotein cholesterol and hemoglobin in the group with CRP high level were significantly lower than those in the group with CRP normal level(P<0 .05) , while the level of low density lipoprotein cholesterol was higher than that(P<0 .05) .Furthermore ,CRP level of 67 cases was nega-tively correlated to serum albumin(r= -0 .46 ,P<0 .05) ,pre-albumin(r= -0 .37 ,P<0 .05) ,high density lipoprotein cholesterol (r= -0 .49 ,P<0 .05) ,while it was positively correlated to low density lipoprotein cholesterol(r=0 .55 ,P<0 .05) .Conclusion The state of microinflammation in hemodialysis patients could be a risk factor of cardiovascular diseases .