ADIPOR2基因多态性与动脉粥样硬化血栓形成性脑梗死的相关性研究

目的：探讨脂联素受体2（ADIPOR2）基因多态性与血清脂联素（APN）水平、颈动脉内膜中层厚度（IMT）及动脉粥样硬化性脑梗死风险的相关性。方法采用病例对照研究，选取2009年9月至2014年9月该院收治的动脉粥样硬化血栓形成性脑梗死患者300例作为观察组，另选取同期300例体检健康者作为对照组。收集所有受试者的临床资料，行颈动脉检查并测量IMT ，检测血清APN水平，测定ADIPOR2基因rs12342多态性，比较组间ADIPOR2基因多态性，分析其与血清APN和IMT的关系。结果 AA基因型与GG基因型相比，患动脉粥样硬化血栓形成性脑梗死的概率增加，差异有统计学意义（OR＝1．903，95％ C I：1．092～2．703，P＝0．011）。与对照组相比，观察组中各基因型亚组IM T值均升高，A PN水平均降低，差异均有统计学意义（P＜0．01）。与GG基因型相比，AA、AG基因型IM T值均升高，APN水平均降低，差异有统计学意义（P＜0．01）。结论 AD‐IPOR2基因多态性可能是中国汉族人动脉粥样硬化性脑梗死发病的一个基因位点。

Study on correlation between genetic polymorphisms of ADIPOR 2 with atherothrombosis cerebral infarction

Objective To explore the relationship between genetic polymorphisms of ADIPOR2 with serum APN level ,inti‐ma‐media thickness(IMT)and atherothrombosis cerebral infarction risk .Methods The case control study was adopted ,300 patients with atherothrombosis cerebral infarction in our hospital from September 2009 to September 2014 were selected as the observation group ,meanwhile contemporaneous 300 individuals undergoing the physical examination were selected as the control group .The clinical data in all the subjects were collected and performed the carotid arterial examination ,the serum APN level was detected ,the rs12342 polymorphism of ADIPOR2 gene was detected .The genetic polymorphisms of ADIPOR2 were compared between the two groups and its relationship with serum APN and IMT was analyzed .Results The probability for suffering from atherothrombosis cerebral infarction in the AA genotype was increased compared with the GG genotype ,the difference was statistically significant (OR=1 .903 ,95% CI:1 .092-2 .703 ,P=0 .011) .Compared with the control group ,the IM T values in various subgenotype groups of the observation group were elevated ,while the APN levels were decreased ,the differences were statistically significant ( P<0 .01) .Compared with the genotype GG ,the IM T values in the genotype AA and AG were increased and APN levels were de‐creased ,the differences were statistically significant (P<0 .01) .Conclusion Genetic polymorphisms of ADIPOR2 maybe a genetic locus for the pathogenesis of Chinese Han people of atherothrombosis cerebral infarction .