| 谷氨酰胺强化的肠内营养减轻大鼠烧伤后肠道损伤的实验研究 |
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| 引用本文： | 孙勇,孙曙光,王良喜,毛学飞,邓向东,潘晓峰.谷氨酰胺强化的肠内营养减轻大鼠烧伤后肠道损伤的实验研究[J].重庆医学,2009,38(18). |
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| 作者姓名： | 孙勇 孙曙光 王良喜 毛学飞 邓向东 潘晓峰 |
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| 作者单位： | 解放军第97医院烧伤整形科,徐州,221004 |
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| 基金项目： | 2007年度南京军区医学科研课题资助项目 |
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| 摘 要： | 目的 观察谷氨酰胺对严重烧伤所致肠黏膜损害的影响.方法 采用30%体表面积Ⅲ度烧伤大鼠模型,随机分成烧伤组(B组)和谷氨酰胺组(G组),两组给予等氮、等热卡、等体积的营养液.G组每天给予30%总氮量的谷氨酰胺,对照组给予等量的甘氨酸.观察烧伤前及烧伤后第1、2、3、4、5、6、7天大鼠的氮平衡变化,同时检测烧伤后血浆D-乳酸、二胺氧化酶(DAO)活性及肿瘤坏死因子(TNF)、内毒素(LPS)的含量.结果 烧伤后两组大鼠的氮平衡、D-乳酸、DAO、TNF及LPS均显著高于烧伤前,差异有统计学意义(P<0.01);G组的氮平衡明显高于B组,而血浆D-乳酸、DAO 活性及TNF、LPS含量均明显低于B组,差异有统计学意义(P<0.05,P<0.01).结论 添加谷氨酰胺的肠内营养可以减轻烧伤后肠道损伤,降低血浆炎症介质水平.
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| 关 键 词： | 谷氨酰胺 肠内营养 烧伤 |
Glutamine-enriched enteral nutrition relieves rat burn-induced intestinal mucosal lesions |
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| SUN Yong,SUN Shu-guang,WANG Liang-xi,et al..Glutamine-enriched enteral nutrition relieves rat burn-induced intestinal mucosal lesions[J].Chongqing Medical Journal,2009,38(18). |
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| Authors: | SUN Yong SUN Shu-guang WANG Liang-xi |
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| Institution: | SUN Yong,SUN Shu-guang,WANG Liang-xi,et al.(Department of Burn Surgery,Plastic Surgery Center,97 Hospital of PLA,Xuzhou 221004,China) |
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| Abstract: | Objective To explore the effect of glutamine on intestine damage after severe burn injury.Methods Ninety Wistar rats were inflicted with 30% total body surface area full thickness burns and then randomly divided into burned control(B) group and glutamine treatment(G) group.Isonitrogenous and isocaloric nutrition supports were provided to both two groups.Rats in G group and B group were administered with glutamine or glycine at the rate of 30% total nitrogen respectively.Nitrogen balance,D-lactate,DAO,and th... |
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| Keywords: | glutamine enteral nutrition burn |
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