| 妊娠期肝内胆汁淤积症患者围生儿预后相关因素分析 |
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| 引用本文： | 常淑芳,郭娟,李建伟,刘建,孙江川.妊娠期肝内胆汁淤积症患者围生儿预后相关因素分析[J].重庆医学,2009,38(6). |
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| 作者姓名： | 常淑芳 郭娟 李建伟 刘建 孙江川 |
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| 作者单位： | 重庆医科大学附属第二医院妇产科,400010 |
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| 摘 要： | 目的 探讨影响妊娠期肝内胆汁淤积症(ICP)患者围生儿预后的因素.方法 从1999年1月至2006年10月重庆医科大学附属第二医院分娩的ICP患者287例中随机抽取未发生新生儿窒息的ICP患者86例和7年间发生新生儿窒息的ICP患者14例,观察比较两组患者瘙痒出现孕周、肝功能指标、脐血流S/D值、胎心监护、分娩方式、羊水混浊的发生率有无差异.结果 发生新生儿窒息的ICP患者脐血流S/D值及血清总胆红素异常率、产前胎心监护胎心基线变异减少或消失率、阴道分娩率、羊水混浊率、早产率明显高于未发生新生儿窒息的ICP患者(P<0.05),但瘙痒出现的孕周、血清总胆汁酸水平及ALT升高程度两组间差异无统计学意义(P>0.05).结论 脐血流S/D值及血清总胆红素升高、产前胎心监护胎心基线变异减少或消失、阴道分娩、羊水混浊、早产与ICP患者新生儿窒息有关,而瘙痒出现的孕周、血清总胆汁酸、ALT等与ICP患者新生儿窒息无关.
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| 关 键 词： | 肝内胆汁淤积症 围生儿 预后 |
Analysis of perinatal prognosis factor of intrahepatic cholestasis during pregnancy |
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| CHANG Shu-fang,GUO Juan,LI Jian-wei,et al..Analysis of perinatal prognosis factor of intrahepatic cholestasis during pregnancy[J].Chongqing Medical Journal,2009,38(6). |
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| Authors: | CHANG Shu-fang GUO Juan LI Jian-wei |
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| Institution: | CHANG Shu-fang,GUO Juan,LI Jian-wei,et al.(Department of Gynecology , Obstetrics,Second Affliated Hospital of Chongqing University of Medical Sciences,Chongqing 400010,China) |
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| Abstract: | Objective To study the factor affecting the perinatal prognosis in intrahepatic chotestasis of pregnancy(ICP).Methods There were 301 patients with ICP From January 1999 to October 2006.The patients with ICP were divided in two groups(14 cases),one group 14 cases with neonatal asphyxia,other group(86 cases) with normal neonate which were randomely selected from 287 patients with ICP.The difference of pruritus,hepatic function,cord blood s/d value,fetal heart mornitoring,deliver way,amniotic fluid turbidness,... |
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| Keywords: | intrahepatic cholestasis of pregnancy(ICP) perinatal prognosis |
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