| 冠心病患者血清sCD40L浓度与胰岛素抵抗 |
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| 引用本文： | 李丽娟,李健,陈隽.冠心病患者血清sCD40L浓度与胰岛素抵抗[J].重庆医学,2010,39(19). |
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| 作者姓名： | 李丽娟 李健 陈隽 |
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| 作者单位： | 重庆医科大学附属第二医院内分泌科,400010;重庆医科大学附属第二医院内分泌科,400010;重庆医科大学附属第二医院内分泌科,400010 |
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| 摘 要： | 目的 了解冠心病(CHD)患者血清sCD40L浓度与胰岛素抵抗的相关性.方法 以CHD患者39例为CHD组,非CHD患者22例为对照组.检测所有研究对象的血清可溶性CD40L(sCD40L)、空腹血糖(FBG)、空腹胰岛素、血脂等指标,并计算胰岛素抵抗指数(HOMA-IR).结果 CHD组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)浓度与对照组比较差异无统计学意义(P>0.05);CHD组高密度脂蛋白胆固醇(HDL-C)浓度显著低于对照组(P<0.05);CHD组血清sCD40L浓度、空腹胰岛素、HOMA-IR明显高于对照组(P<0.05);CHD组血清sCD40L浓度与HOMA-IR、空腹胰岛素、TG、TC、LDL-C呈正相关(P<0.05),与HDL-C呈负相关(P<0.05).结论 CHD患者血清sCD40L水平升高与胰岛素抵抗并存,两者在冠心病、糖尿病的发生、发展中具有一定作用.
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| 关 键 词： | 冠心病 胰岛素抵抗 血清sCD40L |
Serum sCD40L concentration and insulin resistance in patients with coronary heart disease |
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| LI Li-juan,LI Jian,CHEN Juan.Serum sCD40L concentration and insulin resistance in patients with coronary heart disease[J].Chongqing Medical Journal,2010,39(19). |
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| Authors: | LI Li-juan LI Jian CHEN Juan |
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| Institution: | LI Li-juan,LI Jian,CHEN Juan(Department of Endocrinology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China) |
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| Abstract: | Objective To understand the correlation between serum sCD40L concentration and insulin resistance in patients with coronary heart disease(CHD).Methods The patients of CHD(39 cases)were selected as case groups,while the patients of non-CHD(22 cases)were selected as control group.Serum sCD40L,fasting blood glucose,fasting insulin,blood lipid were tested for each subject,and homeostasis mode1 assessment of insulin resistance(HOMA-IR)was calculated.Results Triglyceride(TG),total cholesterol(TC),low density lipo... |
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| Keywords: | coronary heart disease insulin resistance serum sCD40L |
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