| 代谢组学与医药科学研究 |
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| 作者姓名： | Liu CX |
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| 作者单位： | 天津药物研究院药代动力学与药效动力学省部共建国家重点实验室,天津,300193 |
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| 摘 要： | 代谢组学是后基因时代出现的一门新兴"组学"学科,它用反映整体的代谢物图直接认识生理和生化状态,能提供区别于其他"组学"的大量信息。代谢组学已经用于评价实验动物模型和外源物产生的一系列代谢过程和作用机制、靶器官的效应、组织损伤。其应用涵盖疾病诊断、新药研究开发、模型识别和确证研究、新生物标志物的发现、新药筛选、安全性实验和作用机制以及中医药研究等方面。
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| 关 键 词： | 代谢组学 疾病研究 药物开发 药物作用机制 药物安全性 中医药 |
| 文章编号： | 1000-503X（2007）06-0712-07 |
| 收稿时间： | 2007-09-19 |
| 修稿时间： | 2007年9月19日 |
Metabonomics in medical and pharmaceutical research |
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| Liu CX.Metabonomics in medical and pharmaceutical research[J].Acta Academiae Medicinae Sinicae,2007,29(6):712-718. |
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| Authors: | Liu Chang-Xiao |
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| Institution: | Tianjin National Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. |
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| Abstract: | Metabonomics is a new "-omics" science in post-gene time.Metabonomics can directly understand the physiological and biochemical situation by its "metabolome profile" as a whole,and therefore can provide various information that differs from other "-omics".Metabonomics has been applied in disease diagnosis,assessment of animal models,screening of new drugs,evaluation of drug safety,discovery of new biomarkers of toxicity,as well as research of traditional Chinese medicine. |
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| Keywords: | metabonomics disease research pharmaceutical development drug action mechanism drug safety traditional Chinese medicine |
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