肺叶切除术治疗滋养细胞肿瘤肺转移的价值

目的 评价肺叶切除术在滋养细胞肿瘤肺转移治疗中的作用。方法 对45例行肺叶切除术的滋养细胞肿瘤病例进行回顾性分析,其中侵袭性葡萄胎7例,绒癌38例。结果 45例患者经过一定疗程的化疗后,均进行了肺叶切除术。7例侵袭性葡萄胎患者完全缓解。绒癌Ⅲa期患者ll例,平均化疗13个疗程,10例完全缓解,1例部分缓解;Ⅲb期患者17例,平均化疗14.3个疗程,ll例完全缓解,3例部分缓解,3例肿瘤进展死亡;Ⅳ期患者10例,平均化疗15个疗程,6例完全缓解,4例肿瘤进展死亡。45份手术切除病理标本中,27例为出血坏死组织,其中17例患者完全缓解(63％),4例部分缓解,6例肿瘤进展死亡。16例病灶周围有纤维化,其中14例完全缓解(88％),2例部分缓解。2例病理结果为结核。结论滋养细胞肿瘤的治疗措施虽然以化疗为主,但是肺叶切除术对某些选择性病例仍是必要而且有效的治疗手段。病理结果对预后的判断具有一定的指导意义。

Evaluation of surgical resection of pulmonary metastasis of trophoblastic tumour

OBJECTIVE: To evaluate the role of lung lobectomy in the patients of tumor with lung metastases. METHODS: A total of 45 cases of trophoblastic tumor with pulmonary metastases treated by lung lobectomy from 1985-2002 at PUMC hospital was retrospectively analyzed. Seven cases were diagnosed as invasive mole and thirty-eight as choriocarcinoma. RESULTS: Lung lobectomy was performed in all of these patients after several courses of chemotherapy. Seven cases of invasive mole reached complete remission. Eleven cases of choriocarcinoma with stage IIIa had received average 13 courses of chemotherapy, 10 of them reached complete remission. Seventeen cases of choriocarcinoma with stage IIIb had received average 14.3 courses of chemotherapy, 11 of them reached complete remission. Ten cases of choriocarcinoma with stage IV had received average 15 courses of chemotherapy, six of them reached complete remission. In the 45 patients, histologic examination disclosed haemorrhagic necrotic tissue in 27 patients, 17 of them reached complete remission (63%). Histologic examination also revealed fibrosis around the focus in 16 patients, 14 of them reached complete remission (88%). Tuberculosis was found in 2 patients. CONCLUSIONS: Although the development of effective chemotherapy has resulted in improved survival of patients with gestational trophoblastic tumor, lung lobectomy remains an important adjunct treatment in a selected subset of patients. Pathological examinations can help to estimate the prognosis.