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血卟啉光动力疗法对克隆肿瘤细胞生长的影响
引用本文:宁爱兰,张雪艳.血卟啉光动力疗法对克隆肿瘤细胞生长的影响[J].中国医学科学院学报,1991,13(3):219-223.
作者姓名:宁爱兰  张雪艳
作者单位:中国医学科学院肿瘤研究所 北京 (宁爱兰),中国医学科学院肿瘤研究所 北京(张雪艳)
摘    要:血卟啉光动力疗法(简称光疗)是一种肿瘤局部疗法,已在动物与人肿瘤的体内外治疗研究中取得疗效.光疗疗效机理与膜性结构改变和单态氧作用有关。应用光疗治疗食管癌多系首次治疗研究,仅个别为复发病例治疗研究,而一次光疗的延续效应与第二次治疗的连续效应问题尚未见报道.本实验分别用体外培养的人食管癌Eca 109细胞系及经过光疗后的Eca 109细胞建立亚克隆细胞系.观察光疗的连续效应与延续效应.

关 键 词:血卟啉  光动力疗法  肿瘤  细胞生长

The effect of hematoporphyrin photodynamic therapy on the growth of monoclonal cancer cells]
A Ning.The effect of hematoporphyrin photodynamic therapy on the growth of monoclonal cancer cells][J].Acta Academiae Medicinae Sinicae,1991,13(3):219-223.
Authors:A Ning
Institution:Institute of Oncology, Beijing.
Abstract:Three cloned esophageal cancer cell lines, Cu3, Cu4 and Cu6, were established from Eca109 cancer cells, and four cloned esophageal cancer cell lines, Ct1, Ct2, Ct5 and Ct7, were established from Eca109 cancer cells after hematoporphyrin photodynamic therapy. The propagation rate of Cu3, Cu4 and Cu6 was higher than Ct5 and Ct7 before 21 generations, demonstration an anti-propagation effect of hematoporphyrin dynamic therapy on cloned cancer cells. The propagation rate of Ct5 and Ct7 cells was partially recovered after 35 and 27 generations respectively. This was a long term effect of photodynamic therapy. A second course of hematoporphyrin photodynamic therapy was given to the 35th and 27th generations of Ct5 and Ct7 cells, and as a result the propagation rates obviously decreased as compared to the first treatment: thus, a cumulative therapeutic effect was shown. It is suggested that for better cancerocidal effect, continual photodynamic therapy is needed clinically. The shorter the interval between course, the better the therapeutic effect.
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