| 香烟烟油对粒细胞氧合作用活性影响的化学发光研究 |
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| 引用本文： | 张荣泉,邱琦.香烟烟油对粒细胞氧合作用活性影响的化学发光研究[J].中国医学科学院学报,1989,11(1):25-29. |
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| 作者姓名： | 张荣泉 邱琦 |
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| 作者单位： | 上海市防疫站，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所 北京，北京 |
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| 摘 要： | 在香烟烟油(0.26～2.6 mg/ml)作用下,以酵母多糖诱发和鲁米诺或光泽精增强的二种兔全血化学发光强度都呈现浓度相关的抑制效应。Evans蓝排斥试验表明,烟油没有显著的细胞毒性,说明上述抑制现象是粒细胞氧合作用活性,免疫功能受到烟油抑制所致。提示吸烟者粒细胞吞噬功能降低,其结果不仅影响抗感染、抗炎症作用,而且与肿瘤的发生也有一定关系。此外,还分析了烟油抑制效应的可能作用机理。
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| 关 键 词： | 香烟烟油 化学发光 粒细胞 氧合作用 |
Effect of Cigarette-smoke Tar on Oxygenation Activity of Granulocytes Detected by Luminol- and Lucigenin-Enhanced Chemiluminescence Response of Rabbit Whole Blood |
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| Zhang Rongquan,et al.Effect of Cigarette-smoke Tar on Oxygenation Activity of Granulocytes Detected by Luminol- and Lucigenin-Enhanced Chemiluminescence Response of Rabbit Whole Blood[J].Acta Academiae Medicinae Sinicae,1989,11(1):25-29. |
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| Authors: | Zhang Rongquan |
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| Abstract: | Both luminol- and lucigenin-dependent rabbit whole blood chemilumi-nescence showed a concentration-dependent inhibition response to cigarette-smoke tar of 0.26 to 2.6mg/ml. Tar showed no cytotoxicity to granulocytes by Evans blue exclusion. It is suggested that oxygenation activity of granulocytes in smoker's blood could be depressed by tar, resulting in harmful effects on the host defense mechanism with increase of susceptibility to infection and incidence of tumorigenicity. |
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| Keywords: | smoke tar chemiluminescence granulocyte oxygenation |
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