免疫细胞在黄体发育及退化过程中的作用

在哺乳动物卵巢中,黄体是一个重要的内分泌组织,在生殖周期调控与早期妊娠建立的过程中具有举足轻重的作用。在研究黄体发育及其分子调控过程中,我们发现多种类型的免疫细胞存在于黄体,如T淋巴细胞、巨噬细胞、中性粒细胞和嗜酸性粒细胞。这些免疫细胞在黄体发育阶段中积累、支持血管生成和孕激素生产,从而参与黄体功能调节。在黄体退化过程中,前列腺素F2α可以刺激细胞炎性因子和趋化因子的产生,这些因子使免疫细胞进入黄体,并通过炎症反应,增强黄体分解,参与黄体退化过程。因此,本文根据课题组前期研究结果,综述了不同类型的免疫细胞在哺乳动物黄体发育及退化过程中的作用,旨在进一步理解卵巢黄体生物学,同时为临床黄体功能操控提供参考。

Effects of Immune Cells on Luteal Development and Regression in the Mammalian Ovary

Corpus luteum,an important endocrine tissue in mammalian ovary,plays a role in the regulation of reproductive cycle and the establishment of early pregnancy.While studying the luteal development and its molecular regulation,we have discovered a variety of immune cells,such as T lymphocytes,macrophages,neutrophils,and eosinophils,in the corpus luteum.These immune cells accumulate and support luteal angiogenesis and progesterone production during the luteal development,thus participating in the regulation of luteal functions.In luteal regression,prostaglandin F2 can stimulate the production of inflammatory cytokines and chemokines,which help immune cells enter the corpus luteum and enhance the decomposition of corpus luteum through inflammatory reactions.According to our research achievements,we reviewed the roles of different types of immune cells in the development and degradation of mammalian luteal functions,aiming to further understand the biology of corpus luteum and provide a reference for the clinical manipulation of luteal functions.