无症状菌尿与孕晚期阴道B族链球菌定植的关联性分析

目的 分析无症状菌尿(ASB)与孕晚期阴道B族链球菌定植的相关性。方法 以2018年1月至2021年6月建卡随访的4287名孕妇为研究对象,其中伴ASB孕妇为观察组,按1∶4进行匹配不伴ASB孕妇作为对照组,分析ASB与孕晚期阴道B族链球菌定植的相关性。结果 4287名孕妇中,伴ASB孕妇158名,ASB发生率为3.69%,孕晚期B族链球菌定植28例,定植率17.72%;不伴ASB孕妇632名,孕晚期B族链球菌定植44例,定植率6.96%。伴ASB组孕妇孕晚期B族链球菌定植率大于不伴ASB组,差异有统计学意义(χ²=17.666,P<0.001)。Logistic分析结果显示,ASB与孕晚期阴道B族链球菌定植呈正相关(OR=2.577,95%CI=1.509~4.402,P=0.001)。结论 ASB与孕晚期阴道B族链球菌定植呈正相关,早期ASB的筛查与防控对降低孕晚期阴道B族链球菌定植率有重要意义。

Relationship between Asymptomatic Bacteriuria and Vaginal Colonization of Group B Streptococcus in the Third Trimester of Pregnancy

Objective To reveal the relationship between asymptomatic bacteriuria (ASB) and vaginal colonization of group B Streptococcus in the third trimester of pregnancy.Methods A total of 4287 pregnant women who were followed up from January 2018 to June 2021 were enrolled in this study.The pregnant women with ASB were assigned as the observation group,and those without ASB were matched at a ratio of 1∶4 as the control group.Results Among the 4287 pregnant women,158 (3.69%) pregnant women had ASB,including 28 (17.72%) with group B Streptococcus colonization in the third trimester.Among the 632 pregnant women without ASB (control),44 cases (6.96%) had vaginal colonization of group B Streptococcus in the third trimester.The colonization rate of group B Streptococcus in the pregnant women with ASB was significantly higher than that in the pregnant women without ASB (χ²=17.666,P<0.001).Logistic regression showed that ASB was positively correlated with the vaginal colonization of group B Streptococcus in the third trimester of pregnancy (OR=2.577,95%CI=1.509-4.402,P=0.001).Conclusions ASB is positively correlated with the vaginal colonization of group B Streptococcus in the third trimester.The screening,prevention,and control of ASB in the early trimester is of great significance to reduce the vaginal colonization of group B Streptococcus in the third trimester.