减肥对内脏脂肪及胰岛素敏感性参数的影响

目的 探讨减肥对脂肪分布及胰岛素敏感性参数的影响。方法 前瞻性自身对照研究。研究对象为１２名成年人女性单纯肥患者。以低热量高蛋白饮食４周,分别于试验前后进行系列检查。采用计算机断层扫描,测定内脏批肪与皮下脂肪。采用正常血糖高胰岛素和夹技术,测得胰岛素敏感性的各项参数。结果 经饮食减肥治疗,体重、体重指数１腰围、总脂肪量、内脏脂肪、皮下脂肪均显著性下降。而减肥前后的腰臀比、内脏脂 及皮下脂肪占总记量

Effect of weight loss on adipose tissue distribution and insulin sensitivity

OBJECTIVE: To discuss the effect of weight reduction on fat distribution and parameters of insulin sensitivity. METHODS: 12 Caucasian women with simple obesity, aged 21 to 65 years, were treated by low caloric and high protein diet for four weeks. A series of examinations were taken before and after the treat, using computerized tomography for visceral and subcutaneous fat, using euglycemic insulin clamp for parameters of insulin sensitivity. RESULTS: Weight loss was (6 +/- 2) kg (2-11 kg). body mass index (BMI), waist, total fat, visceral fat, and subcutaneous fat reduced significantly. However waist-hip rate, visceral-total fat rate, and subcutaneous-total fat rate did not change significantly. Fasting serum insulin, and fasting insulin-glucose rate decreased significantly. Insulin metabolic clearance rate and, insulin sensitive index increased significantly. Fasting peptide C did not change significantly. CONCLUSIONS: The low caloric and high protein diet can reduce visceral and subcutaneous fat. Weight loss can improve insulin sensitivity and increase insulin metabolic clearance rate.