| 人成纤维细胞产生的抑制因子对肿瘤和转化细胞增殖与分化的影响 |
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| 引用本文： | 宋玉华,吴克复.人成纤维细胞产生的抑制因子对肿瘤和转化细胞增殖与分化的影响[J].中国医学科学院学报,1991,13(1):50-55. |
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| 作者姓名： | 宋玉华 吴克复 |
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| 作者单位： | 中国医学科学院血液学研究所 天津
(宋玉华)，中国医学科学院血液学研究所 天津(吴克复) |
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| 摘 要： | 对人成纤维细胞产生的抑制因子(HFDI)的细胞生长抑制效应进行研究,发现HFDI对肿瘤细胞~3H—TdR掺入抑制是由于使细胞变性坏死或促使细胞有限分化所致;并证明HFDI对PHA刺激的淋巴细胞转化的抑制,也是由于使转化细胞变性坏死或促使细胞向成熟方向发展所致。
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| 关 键 词： | 人成纤维细胞 抑制因子 肿瘤 |
Effect of Human Fibroblast Derived Inhibitor on Tumor and Transformed Cell Proliferation and Differentiation |
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| Song Yuhua Wu Kefu.Effect of Human Fibroblast Derived Inhibitor on Tumor and Transformed Cell Proliferation and Differentiation[J].Acta Academiae Medicinae Sinicae,1991,13(1):50-55. |
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| Authors: | Song Yuhua Wu Kefu |
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| Institution: | Institute of Hematology, Tianjin. |
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| Abstract: | The effect of HFDI (human fibroblast derived inhibitor) on cell growth inhibition and differentiation of J6-1 (leukemia cell line), Namalva (Burkitt's lymphoma cell line), and fresh leukemic bone marrow cell cultures was studied. HFDI was found to inhibit tumor and leukemic cell growth as assayed by 3H-TdR incorporation, cell degeneration and necrosis, and to induce differentiation.We demonstrated that the characteristics of PHA-inhibited lymphocyte transformation were, in fact, identical to those of HFDI-inhibited degeneration and necrosis and HFDI-induced differentiation.It seems that necrosis was related to target cell sensitivity to HFDI. |
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| Keywords: | cell growth inhibitor cell proliferation cell differentiation fibroblast |
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