猴免疫缺陷病毒感染猕猴快速进展型死亡特征

观察猴免疫缺陷病毒（ｓｉｍｉａｎｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙｖｉｒｕｓ，ＳＩＶ）ＳＩＶｍａｃ和ＳＩＶｍａｃ２５１毒株感染猕猴快速进展型死亡的感染特征。方法用ＳＩＶｍａｃ和ＳＩＶｍａｃ２５１静脉接种，实验性感染８０只恒河猴和４只食蟹猴，定期采集静脉血浆进行病毒分离测定血浆病毒水平，间接免疫荧光法测定血浆病毒抗体水平，并取淋巴组织进行常规理组织学检查。结果８４只猕猴感染ＳＩＶｍａｃ和ＳＩＶｍａｃ２

Characteristic immunodeficiency syndrome of rapid fatal type of simian immunodeficiency virus infected monkeys

Objective To observe the characteristic immunodeficiency syndrome of the rapid fatal type of simian immunodeficieny virus (SIV) infected monkeys. Methods Eighty rhesus monkeys and 4 cynomolgus monkeys were intravenously inoculated with SIVmac or SIVmac251. The virus isolation and viral titer, estimation by indirect immunofluroresence and viral antibody were determined periodily from monkeys' plasma; lymph node biopsies were performed for pathohistological examination. Results Twelve out of 84 macaque (14 2%) died of rapid progressive type after inoculation of SIVmac and SIVmac251 in the duration 3 to 4 months. Dying monkeys showed persistent high viremia and low level titre antibody. Eight of 10 pathohistological changes showed severe depletion of lymphiod tissue in spleen and lymph nodes, there were remarkable immunodeficiency with opportunity infection. The other two monkeys appeared moderate lymphoid tissue deletion and hyperplasia without opportunity infections. The survived monkeys' (72/84) lymph nodes biopsies revealed hypoplasia of lymphoid tissue. Conclusions The characteristic immunodeficiency syndrom of rapid fatal type of simian immunodeficiency virus infected monkeys could be made with persistent high viremia, low level antibody, severe lymphoid tissue deletion in lymph nodes and spleen, as well as complicated opportunity infections.