首页 | 本学科首页   官方微博 | 高级检索  
检索        

经鼻持续气道内正压通气治疗对阻塞性睡眠呼吸暂停低通气综合征瘦素水平及代谢紊乱的影响
作者姓名:Huang R  Huang XZ  Wang HG  Li M  Xiao Y
作者单位:1. 中国医学科学院,中国协和医科大学,北京协和医院呼吸科,北京,100730
2. Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing
摘    要:目的评价经鼻持续气道内正压通气(nasal continuous positive airway pressure,nCPAP)治疗对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea/hypopnea syndrome,OSAHS)瘦素水平和代谢紊乱的影响,探讨瘦素水平在OSAHS发病中的作用.方法测定OSAHS患者在nCPAP一夜治疗(18例)和长期治疗(8例,治疗时间7.5个月)前后的血清瘦素浓度,对比治疗前后部分代谢参数的变化.结果nCPAP一夜治疗后,血清瘦素水平下降(8.47±0.62)μg/L vs(7.32±0.64)μg/L,P=0.022],其余参数未见明显变化(P>0.05);血清瘦素水平在nCPAP长期治疗后明显下降并独立于体重指数(body mass index,BMI)(8.35±0.83)μg/L vs(6.05±0.78)μg/L,P=0.036];血清空腹血糖(FBG)和空腹真胰岛素(TI)均在nCPAP长期治疗后明显下降(P值均为0.036),但甘油三酯(TG)和胆固醇(Chol)未见明显变化.结论nCPAP一夜和长期治疗能降低OSAHS的瘦素水平并独立于BMI,OSAHS可能对血清瘦紊水平具有独立的作用;nCPAP长期治疗可改善OSAHS的糖代谢及胰岛素抵抗.

关 键 词:经鼻持续气道内正压  阻塞性睡眠呼吸暂停低通气综合征  瘦素
修稿时间:2003年7月11日

Effects of nasal continuous positive airway pressure on serum leptin concentration and the metabolic parameters in obstructive sleep apnea hypopnea syndrome
Huang R,Huang XZ,Wang HG,Li M,Xiao Y.Effects of nasal continuous positive airway pressure on serum leptin concentration and the metabolic parameters in obstructive sleep apnea hypopnea syndrome[J].Acta Academiae Medicinae Sinicae,2004,26(2):168-171.
Authors:Huang Rong  Huang Xi-zhen  Wang Hui-ge  Li Ming  Xiao Yi
Institution:Department of Respiratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. huangrong0212@163.com
Abstract:OBJECTIVE: To evaluate the effects of nasal continuous positive airway pressure (nCPAP) on serum leptin concentration and the metabolic parameters in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS: Serum leptin levels and true insulin (TI) levels were measured before and after one night nCPAP therapy in 18 patients. Eight patients received regular nCPAP treatment and had no change of body weight (BMI change < or = 1.5 kg/m2 from baseline) were recruited to the reassessment study 7.5 months after therapy. RESULTS: After one night use of nCPAP, there was a significant decrease in serum leptin (8.47 +/- 0.62) microg/L vs (7.32 +/- 0.64) microg/L, P = 0.022] without change in other parameters. After 7.5 months of nCPAP treatment, serum leptin levels continued to decrease significantly without changes in BMI (8.35 +/- 0.83) microg/L vs (6.05 +/- 0.78) microg/L; P = 0.036), and fast blood glucose (FBG) and true insulin (TI) also decreased significantly (P = 0.036) in OSAHS patients. However, triglyceral (TG) and cholesterol (Chol) maintained the pretreatment level (P > 0.05). CONCLUSIONS: OSAHS may have significant effects on the serum leptin levels and the correction of sleep disordered breathing by nCPAP can reduce the serum leptin levels. Decrease of leptin was independent of BMI change. The glucose metabolic disturbance and insulin resistance in OSAHS were improved after 7.5 months of nCPAP treatment.
Keywords:nasal continuous positive airway pressure  obstructive sleep apnea/hypopnea syndrome  leptin  
本文献已被 CNKI 万方数据 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号