| 棉酚和雷公藤单体T7对人精子ATP酶活性的比较研究△ |
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| 引用本文： | Wu F,Zhang Z,Ye W,Qian X. 棉酚和雷公藤单体T7对人精子ATP酶活性的比较研究△[J]. 中国医学科学院学报, 1998, 20(4): 267-270 |
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| 作者姓名： | Wu F Zhang Z Ye W Qian X |
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| 作者单位： | 中国医学科学院中国协和医科大学基础医学研究所北京100005 |
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| 基金项目： | 国家自然科学基金,39670763, |
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| 摘 要： | 目的 比较两种男性节育药棉酚和雷公藤单Ｔ７对人精子ＡＴＰ酶活性的作用。方法 将人精子放入反应体系（８０ｍｍｏｌ／Ｌ ＮａＣｌ,２０ｍｍｏｌ／Ｌ ＫＣ１,３ｍｍｏｌ／Ｌ ＭｇＣｌ２,４０ｍｍｏｌ／Ｌ Ｔｒｉｓ－ＨＣ１,３ｍｍｏＬ ＡＴＰ,５ｍｍｏｌ／ＬＥＤＴＡ）根据所释放的无机磷含量计算ＡＴＰ酶活性。结果 棉酚对人精子ＡＴＰ酶活性具有抑制作用,且呈浓度依赖关系,雷公藤单体Ｔ７则无抑制作用。结论 棉酚
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| 关 键 词： | 精子 ATP酶 棉酚 雷公藤单体T7 男用节育药 |
| 修稿时间： | 1996-12-27 |
Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity |
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| Wu F,Zhang Z,Ye W,Qian X. Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity[J]. Acta Academiae Medicinae Sinicae, 1998, 20(4): 267-270 |
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| Authors: | Wu F Zhang Z Ye W Qian X |
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| Affiliation: | Institute of Basic Medical Sciences, Beijing 100005. |
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| Abstract: | OBJECTIVE: A comparative study was carried out on the effect of two kinds of male contraceptive drugs, gossypol and the abstract of tripterygium wilfordii T7, on the human spermatozoa ATPase activity. METHODS: The specific activity of total ATPase and Na-K ATPase of spermatozoa was assayed in this experiment. RESULTS: (1) The effect of gossypol on the human spermatozoa ATPase activity is inhibitory and concentration-dependent; and (2) The abstract of tripterygium wilfodii T7 has no effect on the human spermatozoa ATPase activity. CONCLUSIONS: The antifertility effects of gossypol and T7 are different. |
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