危重监护室呼吸机相关性肺炎病原菌临床研究

目的　通过对呼吸机相关性肺炎病原菌的构成及耐药情况的研究 ,为临床治疗提供依据。方法　急诊ICU室收治的86例机械通气患者 ,其中 6 4例发生呼吸机相关性肺炎 ,对其致病菌及药敏结果进行回顾性调查。　结果　 6 4例检出 84株致病菌 ,其中革兰阴性细菌 (G-菌 )占 6 9.1% (5 8/ 84 ) ,革兰阳性细菌 (G 菌 )占 19.1% (16 / 84 ) ,真菌占 11.9% (10 / 84 ) ;前 4位致病菌分别为铜绿假单胞菌 (2 9株 ) ,金黄色葡萄球菌 (12株 )肺炎克雷白氏菌 (14株 )白色念球菌 (10株 )。药敏结果显示这类菌株耐药现象严重。　结论　呼吸机相关性肺炎病原菌以G-菌为主 ,呈多重耐药 ,临床上合理使用抗生素至关重要。

Pathogens of pneumonia in patients receiving mechanical ventilation

Objective To analyze the variety of pathogens of lower respiratory tract infection in patients receiving mechanical ventilation and the microbial drug resistance . Methods There were 86 patients institutionalized in ICU which received mechanical ventilation and then pneumonia occurred in 64.The pathogens andtheir drug resistance were reviewed. Results A total of 84 strain pathogens were isolated by microbial culture. The ratio of gram-negative bacteria tototal microorganism isolated was 69.1%(58/84),and the gram-positive bacteria was 19.1%(16/84), and fungi were 11.9%(10/84). Among pathogens the most common were P.aeruginosa (29 strains), S.aureus(12 strains), P.klebsiella (14strain), and Candida albican (10 strains), their drug-resistance-multipleto antimicrobial agents is serious. Conclusion Gram-negative bacteria are the majority of the pathogens seperated from patients receiving mechanical ventilation of pneumonia in ICU.The pathogens show drug-resistance-mutiple to antimicrobial agents,and emphasis is on the rational use of antibiotics.