| 吉非替尼治疗老年晚期肺癌的临床观察 |
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| 引用本文： | 王文璋,王京凯,王幼黎,高举,李娅娜.吉非替尼治疗老年晚期肺癌的临床观察[J].山西医科大学学报,2011,42(3):220-222. |
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| 作者姓名： | 王文璋 王京凯 王幼黎 高举 李娅娜 |
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| 作者单位： | 中国航空工业中心医院胸外科,北京,100012 |
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| 摘 要： | 目的探讨吉非替尼作为老年晚期肺癌一线治疗方案的可行性。方法 15例经病理学或细胞学证实的老年晚期肺癌初治患者口服吉非替尼250 mg/d,直至患者死亡或肿瘤进展或发生不可耐受的毒副反应,服药前和服药后每月复查胸部CT进行肿瘤评估,分析吉非替尼治疗15例老年晚期肺癌疗效、中位肿瘤进展时间以及对相关症状的控制。结果客观有效率为(CR+PR)53.3%,疾病控制率为(CR+PR+SD)86.7%,中位肿瘤进展时间(TTP)为5.4个月,中位生存期(MS)为11.1个月。与药物相关的主要不良反应为皮疹(10例)。结论吉非替尼一线治疗老年晚期肺癌显示出良好的耐受性和有效性。
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| 关 键 词： | 肺癌 吉非替尼 临床疗效 |
Clinical observation of gefitinib in the treatment of advanced lung cancer in elderly patients |
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| WANG Wen-zhang,WANG Jing-kai,WANG You-li,GAO Ju,LI Ya-na.Clinical observation of gefitinib in the treatment of advanced lung cancer in elderly patients[J].Journal of Shanxi Medical University,2011,42(3):220-222. |
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| Authors: | WANG Wen-zhang WANG Jing-kai WANG You-li GAO Ju LI Ya-na |
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| Institution: | WANG Wen-zhang,WANG Jing-kai,WANG You-li,GAO Ju,LI Ya-na(Dept of Thoracic Surgery,Aviation Industry Central Hospital,Beijing 100012,China) |
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| Abstract: | Objective To explore the feasibility of gefitinib as a first-line drug for advanced lung cancer in elderly patients.Methods Fifteen elderly patients with advanced lung cancer confirmed by pathology or cytology were given orally gefitinib 250 mg once a day in initial treatment until death or tumor progression or withdrawal by intolerable reaction.Breast CT scan was performed before and after treatment once a month.The curative effect,disease control rate,median survival time and control of the related sympto... |
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| Keywords: | lung cancer gefitinib clinical protocols |
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