| 前列腺癌神经内分泌分化及其与Ki-67的关系 |
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| 引用本文： | 靳秀平,梁建芳,郑绘霞,肖虹,李宁,王宏坤,程彩霞,高建忠,白瑞兵.前列腺癌神经内分泌分化及其与Ki-67的关系[J].山西医科大学学报,2008,39(12). |
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| 作者姓名： | 靳秀平 梁建芳 郑绘霞 肖虹 李宁 王宏坤 程彩霞 高建忠 白瑞兵 |
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| 作者单位： | 山西医科大学第一临床医学院病理科,太原,030001 |
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| 摘 要： | 目的 研究前列腺癌神经内分泌分化(neuroendocrine differentiation,NED)及Ki-67与前列腺癌预后的关系. 方法 收集有完整临床和随访资料的40例前列腺癌手术切除标本,应用免疫组化Polymer conjugate法检测嗜铬素A(CgA)、神经特异性烯醇化酶(NSE)、突触素(SYN)及增殖指标Ki-67表达情况,同时分析NED与增殖指标Ki-67及Gleason积分的关系.单因素Cox风险模型分析前列腺癌NED与患者术后生存的关系. 结果 40例前列腺癌患者中有11例伴有神经内分泌分化(27.5%),且这组患者的3年生存率明显低于同时期不伴有神经内分泌分化的前列腺癌组(P<0.05).前列腺癌伴NED患者中Ki-67表达水平与不伴有NED的前列腺癌患者比较差异有统计学意义(P<0.05),且NED表达水平与Gleason积分成正相关.单因素Cox回归分析显示前列腺癌术后生存时间与Gleason积分(P<0.05)、NED阳性密切相关(P<0.05).结论 前列腺癌NED与患者术后生存有关,联合检测前列腺癌NED与Ki-67的表达可能能更好地判断前列腺癌的预后.
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| 关 键 词： | 前列腺癌 神经内分泌分化 预后 |
Neuroendocrine differentiation in prostate carcinoma and its correlation with Ki-67 |
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| JIN Xiu-ping,LIANG Jian-fang,ZHENG Hui-xia,XIAO Hong,LI Ning,WANG Hong-kun,CHENG Cai-xia,GAO Jian-zhong,BAI Rui-bing.Neuroendocrine differentiation in prostate carcinoma and its correlation with Ki-67[J].Journal of Shanxi Medical University,2008,39(12). |
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| Authors: | JIN Xiu-ping LIANG Jian-fang ZHENG Hui-xia XIAO Hong LI Ning WANG Hong-kun CHENG Cai-xia GAO Jian-zhong BAI Rui-bing |
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| Institution: | Dept of Pathology;First Clinical Medical College;Shanxi Medical University;Taiyuan 030001;China; |
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| Abstract: | Objective To investigate the prognostic value of neuroendocrine differentiation and the expression of nuclear Ki-67 proliferation antigene in prostate carcinoma. Methods The data of 40 patients with prostate carcinoma were retrospectively analyzed in this study.All the patients were followed up.The immunohistochemical methods were used to investigate the percentage of neuroendocrine differentiation.The tumor specimens were stained by NED markers,neuron specific enolase(NSE),chromogranin(CgA),synaptophysin(S... |
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| Keywords: | Ki-67 |
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