| 实验动物矽肺影像研究 |
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| 引用本文： | 王莹,邓国祥. 实验动物矽肺影像研究[J]. 山西医科大学学报, 2008, 39(8) |
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| 作者姓名： | 王莹 邓国祥 |
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| 作者单位： | 山西医科大学第一临床医学院影像科,太原,030001 |
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| 摘 要： | 目的 通过对大鼠和家兔矽肺模型在高分辨率CT图像和病理结果的对照分析,确定家兔在复制矽肺模型上的可行性.方法 通过气管内注射的方法将石英混悬液灌注入4只大鼠和4只家兔肺内建立矽肺模型.1只大鼠和1只家兔不处理作为对照.2个月后扫描动物即处死,取肺组织进行固定和切片HE染色.在光学显微镜下观察,将病理结果与影像表现作对照分析.结果 灌注石英粉尘悬液后2个月,大鼠的HRCT图像仅能识别肺内大血管和叶、段级支气管结构,肺内的其他结构显示不清.家兔的HRCT图像显示,肺内点状密度增高影,边缘清晰,病理切片证实有早期矽结节形成.结论 大鼠不适合作HRCT研究的模型动物;家兔肺模型提供了可靠的矽肺病变特征,因而可以应用到矽肺高分辨率CT的研究中.
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| 关 键 词： | 矽肺 动物模型 兔 大鼠 高分辨率CT |
Imaging studies of silicosis experimental animal model |
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| WANG Ying,DENG Guo-xiang. Imaging studies of silicosis experimental animal model[J]. Journal of Shanxi Medical University, 2008, 39(8) |
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| Authors: | WANG Ying DENG Guo-xiang |
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| Affiliation: | Dept of Radiology;First Clinical Medical College;Shanxi Medical University;Taiyuan 030001;China |
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| Abstract: | Objective To determine the feasibility of rabbit as an experimental animal for establishing a silicosis model. Methods Four Wistar rats and 4 rabbits were infused with quartz dust suspension into tracheas to establish the silicosis model.One normal rat and one normal rabbit were chosen as the controls.All animals were executed at month 2 after infusion.Lung tissues were fixed and sliced after high resolution computerized tomography(HRCT)scanning.The imaging results were compared with the pathological result... |
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| Keywords: | silicosis animal model rabbit rat high resolution computerized tomography |
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