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过敏性休克猝死豚鼠肺组织内嗜酸性粒细胞趋化因子的变化及法医学意义
引用本文:赵杰,高彩荣,郭相杰,王英元.过敏性休克猝死豚鼠肺组织内嗜酸性粒细胞趋化因子的变化及法医学意义[J].山西医科大学学报,2008,39(3):200-202.
作者姓名:赵杰  高彩荣  郭相杰  王英元
作者单位:山西医科大学法医学院法医病理教研室,太原,030001
基金项目:山西省自然科学基金资助项目(20051090)
摘    要:目的 探讨豚鼠过敏性休克猝死后嗜酸性粒细胞趋化因子(Eotaxin)在肺组织内的表达及法医学意义.方法 12只健康豚鼠随机分为对照组和过敏性休克模型组(n=6).以人血清致敏法建立过敏性休克豚鼠模型,而对照组注射生理盐水.免疫组化法测定Eotaxin在正常豚鼠和过敏性休克模型豚鼠肺组织内蛋白表达.结果 模型组豚鼠肺组织内Eotaxin表达阳性表达显著高于正常对照组,差异有统计学意义(P<0.05).结论 在过敏性休克发生时Eotaxin在肺内阳性表达显著增加,为过敏性休克的判定提供辅助诊断依据.

关 键 词:法医病理学  嗜酸性粒细胞趋化因子  过敏性休克  免疫组化  过敏性休克  猝死  豚鼠  肺组织  嗜酸性粒细胞趋化因子  变化  法医学意义  significance  shock  guinea  pigs  lung  factor  eosinophil  诊断依据  肺内  发生  统计学意义  差异  正常对照组  阳性表达
文章编号:1007-6611(2008)03-0200-03
修稿时间:2007年11月9日

Changes of eosinophil chemotactic factor in lung tissues of guinea pigs with anaphylactic shock and its forensic significance
ZHAO Jie,GAO Cai-rong,GUO Xiang-jie,WANG Ying-yuan.Changes of eosinophil chemotactic factor in lung tissues of guinea pigs with anaphylactic shock and its forensic significance[J].Journal of Shanxi Medical University,2008,39(3):200-202.
Authors:ZHAO Jie  GAO Cai-rong  GUO Xiang-jie  WANG Ying-yuan
Institution:Dept of Forensic Pathology;School of Forensic Medicine;Shanxi Medical University;Taiyuan 030001;China
Abstract:Objective To explore the value of eosinophil chemotactic factor in forensic medicine by observing its expression in lung tissues of guinea pigs with anaphylactic shock.Methods Twelve guinea pigs were divided into two groups:shock group and control group.The guinea pigs were injected with physiological saline in control group,while were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks in shock group.Expression of eotaxin in lung tissues was detected by...
Keywords:forensic pathology  eosinophil chemotactic factor  anaphylactic shock  immunohistochemistry  
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