| 喉鳞癌中CDK2对细胞周期的影响及其意义 |
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| 引用本文： | 刘荣,皇甫辉.喉鳞癌中CDK2对细胞周期的影响及其意义[J].山西医科大学学报,2008,39(5):433-437. |
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| 作者姓名： | 刘荣 皇甫辉 |
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| 作者单位： | 山西医科大学第一临床医学院耳鼻咽喉科,太原,030001 |
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| 摘 要： | 目的 探讨喉鳞癌组织CDK2激酶表达与肿瘤细胞增殖之间的关系. 方法 取手术中获得的50例喉鳞癌组织,12例非典型增生组织和30例声带息肉组织,用免疫组化的方法检测CDK2与PCNA的表达;用流式细胞术检测喉鳞癌组织细胞周期比率. 结果 在喉鳞癌组织中CDK2与PCNA的阳性率表达分别为68.0%和86.0%,显著高于声带息肉组织(P<0.05);并且CDK2的表达与临床分期、病理分级、淋巴转移密切相关,与患者的年龄、性别和原发部位无关. 结论 喉鳞癌中CDK2过度表达可能与肿瘤细胞增殖异常密切相关.在诊断和治疗喉鳞癌中,CDK2可能是一个有重要作用的指标.
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| 关 键 词： | 喉鳞癌 细胞周期 CDK2 增殖细胞核抗原 增殖 喉鳞癌 细胞周期 影响 意义 clinical significance squamous cell carcinoma laryngeal cell cycle 指标 作用 诊断和治疗 异常 性别 年龄 患者 相关 淋巴转移 病理分级 临床分期 阳性率 |
| 文章编号： | 1007-6611(2008)05-0433-04 |
| 修稿时间： | 2007年12月11 |
Effects of CDK2 on cell cycle in laryngeal squamous cell carcinoma and its clinical significance |
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| LIU Rong,HUANG FU-Hui.Effects of CDK2 on cell cycle in laryngeal squamous cell carcinoma and its clinical significance[J].Journal of Shanxi Medical University,2008,39(5):433-437. |
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| Authors: | LIU Rong HUANG FU-Hui |
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| Institution: | Dept of Otorhinolaryngology;First Clinical Medical College;Shanxi Medical University;Taiyuan 030001;China |
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| Abstract: | Objective To investigate the role of CDK2 in cell proliferation in laryngeal squamous cell carcinoma(LSCC). Methods The expression of CDK2 protein and proliferating cell nuclear antigen(PCNA)was analyzed in 50 specimens of LSCC,12 specimens of atypical hyperplasia and 30 specimens of vocal cord polyp obtained during operation by immunohistochemical method.The ratio of cell cycle was determined in LSCC using flow cytometry. Results The positive rates of CDK2 and PCNA in LSCC were 68.0%(34/50) and 86.0%(43/50... |
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| Keywords: | laryngeal squamous cell carcinoma cell cycle CDK2 proliferating cell nuclear antigen proliferation |
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