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代谢综合征患者CAP的改变及阿斯匹林对其的影响
引用本文:李雄,付丽,冷建杭,汪志伟.代谢综合征患者CAP的改变及阿斯匹林对其的影响[J].浙江中医药大学学报,2004,28(6):14-15.
作者姓名:李雄  付丽  冷建杭  汪志伟
作者单位:1. 浙江中医学院附属第二医院,杭州,310006
2. 浙江省杭州市第一人民医院
摘    要:目的:探讨代谢综合征患者血液中循环活化血小板(CAP)的变化及其临床意义.方法:以纤维蛋白原受体(FIB-R)、P-选择素(CD62P)作为分子标志物,FCM三色免疫荧光分析CAP.结果:正常人静止血小板膜表面FIB-R和CD62P表达较低.79例代谢综合征患者血液中表达FIB-R,CD62P的CAP数量与正常人比较差异有显著意义(P<0.001,P<0.01).阿斯匹林治疗后高血压病患者CAP的FIB-R,CD62P表达呈下降趋势(P<0.001,P<0.01).结论:代谢综合征患者血液中FIB-R,CD62P明显增高,阿斯匹林可以显著降低高血压病患者FIB-R,CD62P的表达水平.

关 键 词:血小板活化  纤维蛋白原受体  P-选择素  代谢综合征  阿斯匹林

The Changes of the CAP in Patients with MS and Effects of Aspirin Therapy
Li Xiong,Fu Li,Leng Jianhang,et al Second Hospital Affiliated to Zhejiang College of TCM,HangZhou.The Changes of the CAP in Patients with MS and Effects of Aspirin Therapy[J].Journal of Zhejiang University of Traditional Chinese Medicine,2004,28(6):14-15.
Authors:Li Xiong  Fu Li  Leng Jianhang  Second Hospital Affiliated to Zhejiang College of TCM  HangZhou
Abstract:Objective:To study the clinical meaning of the circularly activate blood platelets(CAP)of the blood in MS.Method:With the FIB-R,CD62P as the numerator marking things,FCM three-color immunity fluorescence,analyze the CAP.Result:The expression of the FIB-R and CD62P in the surface of the quiet blood platelets membrane in the normal person is low.The quantity of the FIB-R and the CD62P in the blood of the 79 patients with MS is significaltly different from the normotensive(P<0.001,P<0.01).The expression of the FIB-R and the CD62P shows to descend(P<0.001,P<0.01) after the Aspirin treatment.Conclusion:The quantity of the FIB-R and the CD62P in the blood of the patients with MS obviously increases high,Aspirin can obviously lower the level of the FIB-R and the CD62P in the blood of the patients with MS.
Keywords:CAP  FIB-R  CD62P  MS  Aspirin
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