金黄色葡萄球菌耐药性的研究

目的:监测金黄色葡萄球菌(SA)的耐药状况,为临床治疗SA感染提供依据。方法:对浙江省中医院2001年6月至2002年5月临床分离出的122例金黄色葡萄球菌进行药敏试验和临床资料分析。结果:临床分离的葡萄球菌在病区、标本分布方面以重症监护病房和痰标本多见。耐苯唑西林金黄色葡萄球菌(MRSA)占70.5％(86/122);苯唑西林敏感金黄色葡萄球菌(MSSA)占29.5％(36/122)。耐万古霉素金黄色葡萄球菌占3.3％(4/122)。结论:耐苯唑西林的金黄色葡萄球菌表现为多重耐药性,且对12种抗生素的耐药率明显高于苯唑西林敏感的葡萄球菌,P<0.01。发现4株耐万古霉素的金黄色葡萄球菌。

Study on the Drug Resistance of SA

Objective: In order to control the nosocomial infections caused by Staphylococci aureus(SA) , the antibiotic resistance status of SA was investigated. Method: 122 strains of SA isolated clinically in Zhejaing Traditional Chinese Medical Hospital from Jun 2001 to May 2002 were tested for their drug-resistance, and the related clinical data were also analyzed. Results : SA isolated clinically was distributed more often in ICU than in other departments, more often in sputum than in other kinds of specimens. The percentages of methicillin-resistant Staphylococcus aureus ( MRSA) , of methicillin-sensitive Staphylococcus aureus (MSSA) , and of vancomycin-resistant Staphylococcus aureus were 70.5% (86/122) , 29.5% (36/122) and 3.3% (4/122) respectively. Conclusion: MRSA showed multiple resistance to antibiotics, the drug-resistant rate to 12 kinds of antibiotics was statistically and significantly higher than that of MSSA. 4 strains were found to be resistant to Vancomycin.