| 小半夏汤对小鼠催吐化学中枢5-羟色胺受体的影响 |
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| 引用本文： | 徐小玉,连建伟.小半夏汤对小鼠催吐化学中枢5-羟色胺受体的影响[J].浙江中医药大学学报,2004,28(3):39-40. |
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| 作者姓名： | 徐小玉 连建伟 |
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| 作者单位： | 浙江中医学院,浙江,杭州,310053 |
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| 摘 要： | 目的:探讨小半夏汤对小鼠催吐化学中枢5-羟色胺受体的影响方法:以小鼠为模型,以顺铂为造模药物,将实验分两部分,一部分为小半夏汤对正常小鼠5-羟色胺受体的影响,取小鼠60只,随机分为正常组、对照组及小半夏汤的组,每组小鼠12只;第二部分,小半夏汤对化疗后小鼠5-羟色胺受体的影响,取小鼠72只,随机分为正常组、造模组、对照组、小半夏汤的三个不同剂量组,每组小鼠12只.给药两周后采血,以免疫组织化学法测定5-羟色胺受体.结果:小半夏汤对正常小鼠5-羟色胺受体无显著影响,而对模型小鼠,可明显降低其5-羟色胺受体水平.结论:小半夏汤止呕机理可能与其对抗5-羟色胺受体升高有关.
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| 关 键 词： | 小半夏汤 催吐 5-羟色胺 受体 |
The Effect of Xiaobanxia Decoction on 5-HT Receptor in Mice CTZ |
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| Xu Xiaoyu,Lian Jianwei Zhejiang College of TCM,Hangzhou.The Effect of Xiaobanxia Decoction on 5-HT Receptor in Mice CTZ[J].Journal of Zhejiang University of Traditional Chinese Medicine,2004,28(3):39-40. |
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| Authors: | Xu Xiaoyu Lian Jianwei Zhejiang College of TCM Hangzhou |
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| Abstract: | Objective: To observe the effect of Xiaobanxia decoction on 5 HT receptor in mice CTZ. Methods: Animal model was induced by injecting DDP into caudal vein of mice. The level of 5 HT receptor in CTZ was measured with immunohistochcmistry. Result: The level of 5 HT receptor was significantly lower than those of model group ( P <0 05).Conclusion: Xiaobanxia decoction can significantly decrease the level of mice 5 HT receptor in CTZ. |
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| Keywords: | Xiaobanxia decoction emetic 5 HT receptor |
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