金丝桃提取物对应激动物模型的抗抑郁作用及其机理研究

目的]探讨金丝桃提取物(EHP)的抗抑郁作用及其作用机制。方法]选取了小鼠强迫游泳应激实验;小鼠尾悬吊应激实验;大鼠慢性应激抑郁模型脑内单胺类神经递质测定实验,研究EHP抗抑郁作用及其作用机制。结果]EHP(320mg/kg、160mg/kg)能显著缩短强迫游泳小鼠及尾悬吊小鼠的不动时间(P<0.05);EHP(320mg/kg、160mg/kg)能显著提高慢性应激抑郁模型大鼠大脑内单胺类神经递质及其代谢物的含量(P<0.05).结论金丝桃提取物具有一定的抗抑郁作用,其抗抑郁作用可能与增加脑内单胺类神经递质的含量有关。

Study on the Antidepressant Effects and Mechanism of Hypericum Perforatum L.(EHP)in Stress-induced Depressive Model

Objective]To study the antidepressant effects and mechanism of Hypericum peratum L.(Elqe).Methods]Forced-swimming test in mice,tail-suspension test in mice mensurating cerebracontents of monoamine neurotransmitters in chronic stress-induced depressive rats done to study the antidepressant effects and mechanism of extract of Hypericum peratum L Results]Immobility time of forced-swimming and tail-suspension in mice which were significantly shortened by EHP (320mg/kg,160mg/kg)(P<0.05);EHP(320mg/kg,160mg/kg)could significantly increase cerebral contents of monomnine neurotransmitters(NE,DA,5-HT,5-HIAA)in chronic stress-induced depressive mice(P<0.05).Conclusion]Extract of Hypericumperforatum L.has the antidepressant,the possible mechanism of EHP for antidepressive action which may be involved in increasing contents of monoamine neurotransmitters.