SF型消洗灵毒性研究

SF型消洗灵(Na_3PO_4、1/4NaOCl、12H_2O)经成都市与北京市卫生防疫站对其消毒性能进行了鉴定,证明其对细菌及病毒均有良好的消毒效果。我们对其进行了急性毒性、蓄积毒性及诱变性的研究。结果小鼠经口LD_(50)为6937mg/kg 体重;雌、雄生大鼠的经口LD_(50)分别为6810及5010mg/kg 体重,属于基本无毒物质。蓄积系数大于12.8,表明无明显蓄积作用。小鼠骨髓微核试验、睾丸染色体畸变分析及Ames 试验均为阴性,未发现有诱变性。我们认为SF 型消洗灵用于食具及水果的洗涤与消毒,如果其残留量不大,是一种有前途的优良消毒洗涤剂。

Studies on Toxicty of SF-Xiao Xi Ling

SF-Xiao Xi'Ling(Na₃PO₄·1/4NaOCl·12H₂O)has been identified forits disinfectant function by Cheng Du(The Municipal EpidemicPrevention Station and Beijing Municipal Centre of Hygiene and EpidemicControl).Experiments demonstrated that SF-Xiao Xi Ling could kill bothvirus and bacteria efficiently.We carried out the following studies,i.e.acute toxicity test,accumulative toxicity test and mutagenicassessment of SF-Xiao Xi Ling.The results showed that the LD₅₀valuewas 6937mg/kg B.W.by the oral route in mice.In rats,study on acuteoral toxicity revealed that the LD₅₀ was 6810mg/kg B.W.in female and5010mg/kg B.W.in male respectively.It belonged to basically untoxic.substance.The cumulation cofficient which was more than 12.8 disclosedits absence of any obvious accumulative effect.Micronucleus test of micebone marrow,testis chromosome aberration analysis in mice and Amestest were all negative.Mutagenicity wasn't discovered.We consider thatSF-Xiao Xi Ling is a promising disinfectant detergent,it can be usedfor cleaning and disinfecting fruits and utensils if the residualquantities are not too much.