免疫炎性反应与颅内囊性动脉瘤基质重塑的组织病理学研究

通过动脉瘤标本的免疫组织化学染色 ,比较破裂与未破裂动脉瘤中免疫炎性反应的表达与分布特点 ,以研究免疫炎性细胞在颅内囊性动脉瘤中的表达 ,及其与动脉瘤基质重塑的相关性。结果发现 :动脉瘤壁中普遍存在以T淋巴细胞和单核巨噬细胞为主的免疫炎性反应 ;破裂动脉瘤瘤壁中这种免疫炎性反应有“灶性”表达的趋势。提示 :颅内囊性动脉瘤瘤壁中基质重塑的实质是一种免疫炎性反应 ,免疫炎性细胞可通过释放蛋白酶造成胶原等基质蛋白的过度降解 ,削弱动脉瘤瘤壁并可能最终导致动脉瘤的破裂。

Histopathological Study on Immunological and Inflammatory Reactions in Matrix Remodeling of Intracranial Saccular Aneurysms

The aim was to study the relationship between immunological and inflammatory reactions and matrix remodeling. Expression and distribution of immunological and inflammatory reactions were analyzed and compared between ruptured and unruptured saccular aneurysms by immunohistopathological stain. Immunological and inflammatory reactions commonly existed which were triggered mainly by T cells and monocyte/macrophages in aneurysm walls, which tended to be “patchy” pattern in ruptured aneurysms. The essence of matrix remodeling process in saccular aneurysms is a kind of immunological and inflammatory reaction which can accelerate enzymatic degradation of collagens by releasing proteinases, weakening aneurysm walls and may eventually lead to aneurysm rupture.