生长抑素八肽治疗急性重型颅脑损伤后应激性溃疡的疗效分析

为评价生长抑素八肽对急性重型颅脑损伤后应激性溃疡的预防和治疗作用 ,对 30例急性重型颅脑损伤患者 (观察组 ) ,除常规的神经外科治疗外 ,同时给予生长抑素八肽制剂 0 .1mg快速静脉滴注 ,每 8h 1次 ,连续治疗 1周 ,观察 3周。对照组为 86例同期急性重型颅脑损伤患者 ,给予常规抑酸治疗。结果 :观察组仅 4例 ( 1 3.3% )出现上消化道出血 ,均在 2 4h内停止出血 ;对照组 1 6例出现上消化道出血 ,占 1 8.6%。结果提示 :生长抑素八肽能有效地预防急性重型颅脑损伤后应激性溃疡的发生 ,而对于已经发生上消化道出血的患者有满意的止血效果

Evaluating the Effect of Sandostatin for Prevention and Treatment of Stress Ulceration in Acute Severe Brain Injury Patients

To evaluate effect of Sandostatin in prevention and treatment of stress ulceration for acute severe brain injury patients, 30 patients with acute severe brain injury (GCS 3～8) were admitted into this study. Besides neurosurgery routine treatments, they received sandostatin during the first 7 days (0.1 mg, per 8 h) and were observed in the next 3 weeks. The other 86 patients with acute severe brain injury, as the controls, just received histamine H 2 antagonist treatment. Only 4 (13.3%) of the 30 patients in sandostatin group suffered from upper gastrointestinal hemorrhage, and all happened in the first 24 h and were controlled within 1 d. In the control group, 16 patients (18.6%) suffered from upper gastrointestinal hemorrhage(P<0.05). Conclusion: sandostatin is effective for prevention and treatment of the stress ulceration in acute sever brain injury patients.