肥胖儿童脂质和糖代谢的研究

应用多种方法从不同角度观察２７例８～１２岁单纯肥胖症儿童及１８例同龄健康儿童的脂质代谢及糖代谢。发现肥胖儿组的总胆固醇、甘油三酯、氧化型低密度脂蛋白及载脂蛋白Ｂ均较对照组明显升高（Ｐ＜０．０５～０．００１），载脂蛋白Ａ降低（Ｐ＜０．０５），脂蛋白（ａ）无明显变化，Ｃ肽及胰岛素较对照组明显升高（Ｐ＜０．０５及０．００１）。腹部Ｂ超检查显示肥胖儿童组脂肪肝发生率占９２．６％（Ｐ＜０．０５）。本研究提示儿童期单纯肥胖症的脂质代谢及糖代谢均有异常改变，必须及早引起重视。

Studies on Serum Lipoprotein Lipids and Apolipoproteins and Insulin Secretion in Simple Obese Children

To study the initial period of fat deposition in human obesity,27 children of over 120% ideal body weight aged 8～12 years old and 18 children of ideal body weight in the same age were observed.It was found that TC,TG,Ox-LDL and apoBwere markedly higher and apoA lower in obese children group than in control group (P<0.05～0.001),there were no difference between two groups in Lp(a).Abdominal ulfrasonic examination showed that 92.6% obese children had fatty liver.It was also found that peptide Cand insulin were higher in obese children group than in control group (P<0.05 and 0.001),and on positive correlation existed between peptide Cand body weight and between insulin and body weight.The investigation results suggested that there were abnormal metabolism of fatty and glycerol in simple obese children.