| 毛冬青甲素体外给药对花生四烯酸诱导的兔血小板聚集和丙二醛生成的影响 |
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| 引用本文： | 杨涛,蔺桂芬,王科大,姜铭,唐玉,陈桂君,李伍善,金敬善.毛冬青甲素体外给药对花生四烯酸诱导的兔血小板聚集和丙二醛生成的影响[J].首都医学院学报,1992(3). |
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| 作者姓名： | 杨涛 蔺桂芬 王科大 姜铭 唐玉 陈桂君 李伍善 金敬善 |
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| 作者单位： | 首都医学院药理学教研室，首都医学院药理学教研室，首都医学院药理学教研室，首都医学院药理学教研室，首都医学院药理学教研室，北京市中医研究所生化室，北京市中医研究所生化室，北京市中医研究所生化室 |
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| 摘 要： | 研究了毛冬青甲素体外给药对花生四烯酸诱导兔血小板聚集和聚集液中过氧化脂质含量变化的影响。结果表明,毛冬青甲素在较大样本中可抑制花生四烯酸诱导的血小板聚集和过氧化脂质的生成,两者间具有一定的相关性,表明毛冬青甲素抗血小板作用可能与抑制过氧化脂质有关。由于后者的生成量与花生四烯酸代谢活性产物TxA_2的生成有近似等摩尔增加的关系,故推测毛冬青甲素对TXA_2的合成有阻断作用,这种作用可能为毛冬青甲素抗血小板功能的作用机制。
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| 关 键 词： | 毛冬青甲素 血小板聚集 MDA TXA_2 |
The Effect of Ilexonine a Administration in Vitro on Platelet Aggregation and Malondialdehyde Formation Induced by Arachidonic Acid in Rabbit |
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| Yang Tao,Lin Guifen,Wang Keda,Jiang Ming,Tang Yu.The Effect of Ilexonine a Administration in Vitro on Platelet Aggregation and Malondialdehyde Formation Induced by Arachidonic Acid in Rabbit[J].Journal of Capital University of Medical Sciences,1992(3). |
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| Authors: | Yang Tao Lin Guifen Wang Keda Jiang Ming Tang Yu |
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| Institution: | Yang Tao,Lin Guifen,Wang Keda,Jiang Ming,Tang Yu Department of Pharmacology,Capital Institute of Medicine Chen Guijun,Li Wushan,Jin Jingshan Department of Biochemistry,Beijing Institute of China Traditional Medicine |
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| Abstract: | This paper reported the effect of ilexonine A (IA) administration in vitro on rabbit platelet aggregation induced by arachidonic acid (AA) in vitro, and the change of malon- dialdehyde (MDA)level in aggregated platelet suspension. The results showed that IA could inhibit platelet aggregation and MDA formation induced by AA. A certain correlation was shown, Between inhibiting rate of aggregation and decrease of MDA level, suggesting the antiplatelet effect of IA might be related to its inhibiton of the formation of MDA. According to MDA is the parameter of thromboxane A_2 (TXA_2) synthesis (TXA_2 is an active metabo- lite of AA during platelet activation), we hypothesiz that IA might interfere with the TXA_2, formation and it may be the mechanism of the antiplatelet effect of ilexonine A. |
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| Keywords: | ilexonine A platelet aggregation MDA TXA_2 |
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