大肠埃希菌和肺炎克雷伯菌3年药敏结果分析

通过 5种抗生素 :头孢他啶 (CAZ)、头孢噻肟 (FTX)、头孢曲松 (CRO)、氨曲南 (ATM )、亚胺硫霉素 (IMP)对大肠埃希菌 (eco)和肺炎克雷伯菌 (kpn)的最小抑菌浓度 (MIC)的统计分析 ,发现 :①ATM的敏感率有所上升 ;②CAZ、IMP的抗菌活性依然强大 ;③ 1 999年kpn的药物敏感性明显下降 ;④采用K B法测得 1 999年 2种菌的超广谱β 内酰胺酶 (ESBLs)产生率约为 2 3.1 % ( 2 1 /88) ,其中kpn占 61 .9% ( 1 3/2 1 ) ,明显高于eco的 38.1 % ( 8/2 1 )。

3-years Antimicrobial Susceptibility Analysis of Escherichia coli and Klebsiella Pnenumoniae

From Jan 1996 to May 1999,the antimicro bial susceptibility of Escherichia coli and Klebsiella pnenumoniae to ceftazidime(CAZ), aztreonam(AZT), cefotaxime(CTX), ceftriaxone(CRO) and imipenem(IMP) were tested.The minium inhibitory concentration(MIC) testing from Jan 1996 to May 1999 was made for the antimicrobial suscepitibility of E.coli and K. pneumoniae; the Disk diffusion from May 1999 to Oct 1999 was tested for ESBLs in E.coli and K.pneumoniae.The results showed: ① the susceptibility in AZT increased; ② the susceptibility in CAZ, IMP was still strong; ③ the susceptibility of K.pneumoniae to CAZ, CTX, CRO in 1999 decreased obviously; ④ through the method of K-B, it was found that the rate of ESBLs pro duction in E. coli and K. pneumoniae in 1999 is 23.1%(21/88), the rate of K.pneumoniae in these 21 ESBLs-producing becteria is 61.9%(13/21), which is much higher than that of E.coli(38.1%, 8/21).