早产儿游离肉碱和酰基肉碱代谢变化特点

目的 讨论早产儿肉碱代谢的特点。方法 选取2015 年4 月-2016 年12 月出生的1 992 例早产儿和 4 035 例正常足月儿血滤纸片，采用串联质谱技术检测样本中31 种肉碱含量。结果 除癸酰肉碱（C10）与癸二烯 酰肉碱（C10 ∶ 2）外，其余肉碱在早产组与正常对照组比较有差异（P <0.05）；与正常对照组比较，早产儿组 的大部分短链酰基肉碱和中链酰基肉碱血浆含量较高，大部分长链酰基肉碱含量较低。结论 早产儿肉碱代谢 水平与正常足月儿存在差异，临床医生应根据早产儿特殊的肉碱代谢水平提供住院期间的合理营养。

Metabolic Alteration of free Carnitine and Acylcarnitine profiles in premature neonates

Objective To investigate the metabolic alteration of free Carnitine and Acylcarnitine profiles in premature neonates. Methods The dry blood spots samples were collected from 1,992 premature neonates and 4,035 full-term neonates delivered in our hospital from 2015 to 2016. The samples were subjected to analyze 31 kinds of Carnitine using the Tandem Mass Spectrometry. Results All carnitine except C10 and C10: 2 were changed significantly compared with that in full-term neonates. Compared with the full-term neonates, most of the mediumchain and short-chain acyl-carnitine were increased while most of the high-chain acyl-carnitine were decreased in the premature neonates. Conclusions Premature neonates exert totally different characteristic of carnitine metabolism; thus, proper nutrition strategies should be provided for the premature neonates during hospitalization.