首页 | 本学科首页   官方微博 | 高级检索  
检索        

中药多糖对红细胞膜相CD35免疫活性的调节作用
引用本文:刘景田,党小军,王惠萍,张洁.中药多糖对红细胞膜相CD35免疫活性的调节作用[J].中国现代医学杂志,2002,12(1):7-9.
作者姓名:刘景田  党小军  王惠萍  张洁
作者单位:陕西省人民医院免疫研究室,西安,710068
摘    要:研究黄芪、灵芝、茯苓、党参、当归、天花粉等中药多糖对红细胞膜相CD35免疫活性的调节作用。方法 :采用 10 ?35单克隆抗体阻断试验 ,比较以上中药多糖在 10 ?35单克隆抗体阻断前后红细胞膜相CD35活性的变化。结果 :4 0例健康献血员和 30例恶性肿瘤患者的红细胞经以上中药多糖作用后 ,其RBC .C3bRR与对照组相比明显提高 (P <0 .0 1)。用 10 ?35单克隆抗体阻断恶性肿瘤患者的红细胞膜相CD35后 ,其RBC .C3bRR明显下降 (P <0 .0 1)。用以上中药多糖作用过的补体致敏酵母菌作红细胞RBC .3bRR试验 ,其花环率无明显变化 (P >0 .0 5 ) ,而将以上中药多糖作用过的红细胞作红细胞RBC .C3bRR试验 ,其花环率明显升高 (P <0 .0 1)。结论 :研究说明以上中药多糖能增强健康献血员和恶性肿瘤患者的红细胞免疫功能 ,并提示以上中药多糖调节红细胞膜相CD35免疫活性的机制 ,与补体致敏酵母菌无关 ,而与红细胞膜相CD35活性有关。

关 键 词:CD35单克隆抗体  中药多糖  红细胞免疫
修稿时间:2002年7月16日

THE STUDY ON THE RED CELL MEMBRANCE PHASE C3b RECEPTOR'S ACTIVITY REGULATED BY CHINESE MEDICINE POLYSACCHARIDES
Liu Jingtian,Dang Xiaojun,Wang Huiping,et al..THE STUDY ON THE RED CELL MEMBRANCE PHASE C3b RECEPTOR''S ACTIVITY REGULATED BY CHINESE MEDICINE POLYSACCHARIDES[J].China Journal of Modern Medicine,2002,12(1):7-9.
Authors:Liu Jingtian  Dang Xiaojun  Wang Huiping  
Institution:Liu Jingtian,Dang Xiaojun,Wang Huiping,et al. Research of immunology,Shanxi People's Hospital,Xi'an 710068
Abstract:Objective:To study the regulation of Astragalus membranaceus?Ganoderma?Poria cocos Angelica Sinensis codonopsis pilosula.Trichosanthes kirilowii on the activation of the red cell membrane phase CD35.Method:The red cell of 40 healthiness and 20 patients with malignant tumors were treated with Chinese medicine polysaccharides,then the block test of 10% CD35 monoclone antibody was adopted to compare the activity of red cell CD35 before and after the block.Results: The rosette rate of red cell C3b receptor was higher before block ( P <0.01),and lower after block ( P <0.01).Conclusions:The Chinese medicine polysaccharides can improve the immune effect of healthiness and patients of malignant tumors.It can regulate the immune effect of red cells and its mechanism is related to the activity of red cell membrane phase CD35.
Keywords:CD35 Monoclone Antibody  Red Cell  Chinese Medicine Polysaccharide
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中国现代医学杂志》浏览原始摘要信息
点击此处可从《中国现代医学杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号