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慢性和慢性重型乙型肝炎患者外周血单核细胞TOLL样受体2的变化及其与白细胞介素6的关系
引用本文:尉秀清,文卓夫,郑丰平,姚集鲁.慢性和慢性重型乙型肝炎患者外周血单核细胞TOLL样受体2的变化及其与白细胞介素6的关系[J].中国现代医学杂志,2008,18(9):1201-1204.
作者姓名:尉秀清  文卓夫  郑丰平  姚集鲁
作者单位:1. 中山大学附属第三医院,消化内科,广东,广州,510630
2. 中山大学附属第三医院,感染科,广东,广州,510630
摘    要:目的探讨慢性乙型肝炎和慢性重型乙型肝炎患者外周血单核细胞TOLL样受体2(TLR2)的变化情况及其意义。方法用流式细胞仪检测30例正常对照者、31例慢性乙型肝炎患者和30例慢性重型乙型肝炎患者外周血单核细胞表面TOLL样受体2的表达,ELISA法检测上述患者血清白细胞介素6(IL-6)的水平。结果正常对照组、慢性乙型肝炎组和慢性重型乙型肝炎组外周血单核细胞TLR2的平均免疫荧光强度和外周血清IL-6水平分别为(21.5±2.7)、(39.0±4.1)、(47.7±21.4)MFI和(11.5±7.2)、(40.8±31.2)、(77.6±33.3)ng/L,自正常对照组到慢性乙型肝炎组及慢性重型乙型肝炎组外周血单核细胞TLR2表达强度和外周血清IL-6水平均依次升高,且各组间比较差异均具有显著性(P<0.05);外周血单核细胞TLR2表达水平与血清IL-6表达水平呈显著正相关,相关系数γ=0.769,P<0.05。结论TLR2可能与慢性乙型肝炎及慢性重型乙型肝炎的发病有关。

关 键 词:乙型肝炎  TOLL样受体2  白细胞介素6  慢性乙型肝炎  重型乙型肝炎  肝炎患者  外周血单核细胞  TOLL  样受体  变化  血清白细胞介素  相关系数  chronic  severe  hepatitis  B  patients  serum  peripheral  blood  monocytes  receptor  发病  表达水平  比较差异  表达强度  荧光强度  免疫
文章编号:1005-8982(2008)09-1201-03
修稿时间:2007年10月11

Correlation between Toll-like receptor 2 on peripheral blood monocytes and serum IL-6 in patients with chronic and chronic severe hepatitis B
WEI Xiu-qing,WEN Zhuo-fu,ZHENG Feng-ping,YAO Ji-lu.Correlation between Toll-like receptor 2 on peripheral blood monocytes and serum IL-6 in patients with chronic and chronic severe hepatitis B[J].China Journal of Modern Medicine,2008,18(9):1201-1204.
Authors:WEI Xiu-qing  WEN Zhuo-fu  ZHENG Feng-ping  YAO Ji-lu
Institution:WEI Xiu-qing1,WEN Zhuo-fu1,ZHENG Feng-ping1,YAO Ji-lu2(1.Department of Digestive Diseases,2.Department of Infectious Diseases,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510630,P.R.China)
Abstract:Objective To study the change of TLR2 on peripheral blood monocytes(PBMCs) and its role in the pathogenesis of chronic hepatitis B and chronic severe hepatitis B.Methods The expression of TLR2 on 10000 CD14+ PBMCs was determined by flow cytometer in 30 healthy controls,31 patients with chronic hepatitis B and 30 patients with chronic severe hepatitis B.The level of serum interleukin-6(IL-6) was determined by ELISA.Results The values of TLR2 on PBMCs and serum IL-6 of the groups of healthy control,patients w...
Keywords:hepatitis B  toll-like receptor 2  interleukin-6  
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