| 重症急性胰腺炎T淋巴细胞免疫功能变化及乌司他丁早期干预的实验研究 |
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| 引用本文： | 张志栋,李勇,焦志凯,范立侨,王冬,赵雪峰.重症急性胰腺炎T淋巴细胞免疫功能变化及乌司他丁早期干预的实验研究[J].中国现代医学杂志,2008,18(15):2176-2179. |
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| 作者姓名： | 张志栋 李勇 焦志凯 范立侨 王冬 赵雪峰 |
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| 作者单位： | 河北医科大学第四医院,河北,石家庄,050011 |
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| 摘 要： | 目的 观察大鼠SAP动物模型及鸟司他丁干预时T淋巴细胞免疫功能变化.方法 建立SD大鼠SAP组、假手术组(F组,对照组)、药物治疗组模型,检测血T淋巴细胞百分比率及乌司他丁干预时CD3 、CD4 、CD8 百分比率、CD4 /CD8 比值含量的变化.结果 SAP时CD4 百分比率、CD4 /CD8 比值、CD3 百分比率、CD8 百分比率均明显降低(P<0.01或P<0.05);乌司他丁治疗组(W2h、W6h)CD4 百分比率、CD4 /CD8 比值均分剐明显升高(P<0.01或P<0.05);乌司他丁治疗组(W6h)CD3 百分比率明显升高(P<0.05).结论 SAP时血液T淋巴细胞CD3 、CD4 、CD8 百分比率、CD4 /CD8 比值不同程度明显降低;乌司他丁可明显提高SAP时T淋巴细胞免疫功能.
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| 关 键 词： | 重症急性胰腺炎 T淋巴细胞免疫 乌司他丁 |
Change of T lymphocyte immune in SAP rats and experimental study on the intervention of Ulinastatin in early period |
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| ZHANG Zhi-dong,LI Yong,JIAO Zhi-kai,FAN Li-qiao,WANG Dong,ZHAO Xue-feng.Change of T lymphocyte immune in SAP rats and experimental study on the intervention of Ulinastatin in early period[J].China Journal of Modern Medicine,2008,18(15):2176-2179. |
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| Authors: | ZHANG Zhi-dong LI Yong JIAO Zhi-kai FAN Li-qiao WANG Dong ZHAO Xue-feng |
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| Institution: | ZHANG Zhi-dong,LI Yong,JIAO Zhi-kai,FAN Li-qiao,WANG Dong,ZHAO Xue-feng (Department of General Surgary,Forth Affiliated Hospital of Hebei Medical University,Shijiazhuang,Hebei 050011,P.R.China) |
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| Abstract: | Objective] To observe the change of T lymphocyte immune function and the experiment study on the intervention of Ulinastatin in severe acute pancreatitis (SAP) rats in early stage. Methods] Establish SD rats model of SAP group,false operation group and Ulinastatin group. The ratio of CD3+, CD4+, CD8+ in T lymphocyte and the ratio of CD4+/CD8+ was examined with FCM. Results] Compared with same time control groups (F group), the CD4+ percentage, the CD3+ percentage, the CD8+ percentage, CD4+/CD8+ ratio in ... |
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| Keywords: | severe acute pancreatitis T lymphocyte immune Ulinastatin |
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