老年动脉粥样硬化患者血清胰岛素样生长因子-1的检测及其与脂代谢的相关性分析

目的探讨老年动脉粥样硬化患者血清胰岛素样生长因子-1(IGF-1)的水平及其与脂质代谢的关系。方法检测60例动脉粥样硬化(AS)患者(其中冠心病25例,脑梗死35例)血清IGF-1、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-CH)及低密度脂蛋白胆固醇(LDL-CH)水平,并与28例健康中青年人、22例健康老年人作比较,同时还分析了血清IGF-1水平与其余各项指标的相关性。结果健康老年人血清IGF-1水平明显低于正常中青年人(P<0.05);老年AS组的IGF-1水平低于两对照组(P<0.05);老年AS组的TC、TG、LDL-CH均高于老年对照组。(依次P<0.01、P<0.01、P<0.05);冠心病患者的血清IGF-1和血脂水平与脑梗死患者比较,差异无显著性(P>0.05)。老年AS组IGF-1水平与TC、TG、LDL-CH呈负相关(依次P<0.01、P<0.01、P<0.05),而与HDL-CH无相关性(P>0.05)。结论以上提示血清IGF-1与衰老、AS的形成及脂质代谢紊乱密切相关。

Determination of serum insulin-like growth factor-1 (IGF-1) and analysis of correlation between its level and lipid metabolic disorder in aged arteriosclerosis

Objective] To investigate the serum level of IGF-1 and the correlation between serum IGF-1 level and the disorder of Lipid metabolism in aged arteriosclerosis. Method] Serum level of IGF-1, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-CH) and low density lipoprotein cholesterol (LDL-CH) in 60 cases of aged arteriosclerosis (25 coronary cases of heart disease and 35 cases of cerebral Infarction)were detected, and were compares with that in 28 cases of healthy adults (25~45 years old) and that in 22 cases of healthy aged control (61~85 years old). Meanwhile the correlations of serum IGF-1 with other indexes were also analysed. Results] Serum IGF-1 level in ages healthy control was obviously lower than that in healthy adults(P <0.05). Serum IGF-1 level in aged arteriosclerosis group was remarkably lower than that in aged healthy the two groups of normal controls (P <0.05). The levels of TC, TG and LDL-CH in aged arteriosclerosis group were significantly higher than that in aged healthy control (P <0.01, P <0.01, P <0.05). Level of serum IGF-1 and lipid in aged coronary heart disease was not remarkably different with cerebral Infarction (P >0.05). In aged arteriosclerosis group, the serum IGF-1 level was negatively correlated with TC, TG and LDL-CH level (P <0.01, P <0.01, P <0.05), but without correlation with HDL-CH level (P >0.05). Conclusion] Based on the above results, it could be concluded that there is a close relationship between the change of serum IGF-1 and the disorder of lipid metabolism in aged arteriosclerosis, IGF-1 may play a certain role in the course of occurrence and development in senility and arteriosclerosis.