蓝染料法乳腺癌前哨淋巴结活检的应用价值

目的研究蓝染料法在乳腺癌前哨淋巴结（sentinel lymph node，SLN）活检的应用价值。方法95例期乳腺癌患者，采用亚甲蓝为示踪剂行SLN定位活检，继行腋窝淋巴结清扫，对SLN和非SLN淋巴结分别病理检查。结果SLN检出成功率为97．89％（93／95）；准确性为97．85％（91／93）；灵敏性为91．67％（22／24）：假阴性率为8．33％（2／24）；特异性为100％（71／71）。结论蓝染料乳晕区皮下注射SLN定位活检方法的成功率高，能较准确地预测腋窝淋巴结状态。

Clinical value of sentinel lymph node biopsy in breast cancer with blue dye

Objective] To study the value of blue dye method of sentinel lymph nodes (SLN) biopsy in breast cancer and its clinical significance. Methods] 95 cases of T1～2 breast cancer patients with clinical node-negative underwent intraoperative lymphatic mapping using blue dye, then a complete axillary node dissection were performed, SLN and non-SLN lymph node underwent pathological investigation respectively. Results] SLN was successfully identified in 97.85% (93/95) patients, accuracy rate was 97.85% (91/93), sensitivity rate was 91.67% (22/24), false negative rate was 8.33%(2/24) and specificity rate was 100%(71/71). Conclusions] Intraoperative lymphatic mapping using blue dye can accurately identify SLN, and SLN biopsy can accurately predict the condition of axillary nodes.