首页 | 本学科首页   官方微博 | 高级检索  
检索        

慢性稳定性心绞痛合并糖尿病患者循环microRNA-92a表达研究
引用本文:王虹,林英忠,周莹,陆红梅,陆山河,罗程,赵林.慢性稳定性心绞痛合并糖尿病患者循环microRNA-92a表达研究[J].中国现代医学杂志,2012,22(6):26-29.
作者姓名:王虹  林英忠  周莹  陆红梅  陆山河  罗程  赵林
作者单位:1. 广西壮族自治区人民医院心内科,广西南宁,530021
2. 广西壮族自治区人民医院中心实验室,广西南宁,530021
基金项目:广西省医药卫生重点科研课题(No:2010026)
摘    要:目的了解循环miR-92a在慢性稳定性心绞痛(SAP)合并2型糖尿病患者中的表达,探讨循环miR-92a在冠心病临床应用的可能性。方法分析比较慢性稳定性心绞痛合并2型糖尿病患者、SAP无糖尿病合并症患者循环miR-92a表达。结果方差成份分析,糖尿病对SAP循环miR-92a表达的贡献(偏差平方和16.676)是年龄对SAP循环miR-92a表达贡献(偏差平方和2.474)的6倍多。以年龄为协变量,协方差分析SAP合并糖尿病病例入院次日循环miR-92a表达水平显著高于SAP无糖尿病合并症病例(F=21.86,P=0.001)。SAP合并糖尿病病例多支血管病变发生率73.3%(22/30)显著高于SAP无糖尿病合并症病例多支血管病变发生率51.2%(44/86)(χ2=4.458,P=0.035)。结论 SAP合并糖尿病病例循环miR-92a表达增高。SAP合并糖尿病病例较无糖尿病病例冠脉病变严重。提示针对循环miR-92a表达增高的合并糖尿病的SAP进行干预治疗的临床实际应用价值值得进一步深入研究。

关 键 词:心绞痛  糖尿病  microRNA  表达

Circulatory level of microRNA 92a in patients of stable angina pectoris with diabetes meilitus
WANG Hong , LIN Ying-zhong , ZHOU Ying , LU Hong-mei , LU Shang-he , LUO Cheng , ZHAO Lin.Circulatory level of microRNA 92a in patients of stable angina pectoris with diabetes meilitus[J].China Journal of Modern Medicine,2012,22(6):26-29.
Authors:WANG Hong  LIN Ying-zhong  ZHOU Ying  LU Hong-mei  LU Shang-he  LUO Cheng  ZHAO Lin
Institution:1.Department of Cardiovascular Disease,2.Core Laboratory,Guangxi People’s Hospital,Nanning,Guangxi 530021,P.R.China)
Abstract:【Objective】 To investigate circulatory level of microRNA 92a(miR-92a) in patients with stable angina pectoris(SAP) complicated with type 2 diabetes mellitus(T2DM).【Methods】 To determine the regulation of miR-92a,we detected it in peripheral blood mononuclear cells of patients of SAP with or without T2DM.Based on the circulating miR-92a in patients with SAP,the influence factors were explored with variance component model.【Results】 Contribution of T2DM was six times higher than age in miR-92a expression according to variance component model(sum of squared deviations were 16.676 vs 2.474).MiR-92a expression was higher in patients with T2DM than those without T2DM(F =21.86,P =0.001).The rate of multivessel coronary artery lesions was higher in patients of SAP with T2DM than those without T2DM(73.3% vs 51.2%,P =0.035).【Conclusion】 MiR-92a is up-regulation in patients with SAP complicated with T2DM.The rate of multivessel coronary artery lesions is higher in patients with T2DM than those without T2DM.It implies miR-92a could be used as blood biomarker to prevent SAP complicated T2DM development.
Keywords:angina pectoris  diabetes mellitus  microRNA  expression
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号