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糖尿病患者T,B细胞亚群的研究
引用本文:孙明谨,曾玉琴,李雪锋,朱大菊.糖尿病患者T,B细胞亚群的研究[J].中国现代医学杂志,2005,15(22):3455-3457.
作者姓名:孙明谨  曾玉琴  李雪锋  朱大菊
作者单位:郧阳医学院附属太和医院内分泌科,湖北十堰442000
摘    要:目的 研究糖尿病患者T,B细胞亚群细胞的变化。方法 应用流式细胞术测定34例1型糖尿病患者及38例2型糖尿病患者T细胞亚群(CD3、CD4、CD4/CD8及B细胞、)并与正常对照组28例作比较。结果 两组糖尿病患者CD3、CD4、CD4/CD8、B细胞水平较对照组均有显著降低(P〈0.01),CD8细胞显著升高(P〈0.01)。1型糖尿病与2型糖尿病患者相比:CD3、CD4及CD4/CD8在1型糖尿病患者中下降更明显(P〈0.05)。结论 1型糖尿病和2型糖尿病都存在细胞免疫功能紊乱,1型糖尿病患者细胞免疫功能损害更严重。

关 键 词:1型糖尿病  2型糖尿病  T细胞亚群
文章编号:1005-8982(2005)22-3455-03
收稿时间:2005-01-06
修稿时间:2005-01-06

Study of T cell subsets and B cell subsets in patients with diabetes mullitus
SUN Ming-jin,ZENG Yu-qin,LI Xue-feng,ZHU Da-li.Study of T cell subsets and B cell subsets in patients with diabetes mullitus[J].China Journal of Modern Medicine,2005,15(22):3455-3457.
Authors:SUN Ming-jin  ZENG Yu-qin  LI Xue-feng  ZHU Da-li
Institution:Department of Endocrinology, Taihe Hospital of Yunyang Medical College, Shiyan, Hubei 442000, P.R.China
Abstract:Objective] To study the dynamic change of T cell subsets and B-cell subsets in the patients with diabetes.Methods] Expression of CD3,CD4,CD8,CD4/CD8,B-cells on peripheral lymphocytes in 34 patients with type 1 diabetes and 38 patients with type 2 diabetes were determined with flow cytometry and compared with 28 normal controls.Result] The percentage of CD3,CD4,CD4/CD8,B-cells decreased significantly in diabetes groups compared with that of controls(P <0.01),The percentage of CD8 was significantly higher in diabetes groups than that in normal control group(P <0.01).The percentage of CD3,CD4,CD4/CD8,B-cells decreased significantly in type 1diabetes groups compared with that of type 2 diabetes group(P <0.05).Conclusions] These results indicated that there are significant abnormality of cell-mediated immunity in type 1 diabetes and type 2 diabetes patients and the abnormality are more significant in type 1 diabetes patients.
Keywords:type 1 diabetes  type 2 diabetes  T cell subsets
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