多发腔隙性脑梗死脑血管功能改变的临床意义

目的：观察多发腔隙性脑梗死(MU)不同时期脑血管功能变化的临床意义。方法：依发病时间将200例MLI患者分成急性MLI组及慢性MU组。同时选取年龄、性别及既往史与前两组匹配的脑血管病危险因素组(CVDRF)及健康对照组(NC)各60例。用脑血管血液爱力学指标估价脑血管功能。结果：与NC组相比，MLI、CVDRF组脑循环显著异常。与CVDRF组相比，MLI组脑循环亦显著异常。与MLI急性组相比，慢性组脑循环有部分改善。MLI、CVDRF组，均出现脑血管弹性及自动调节功能下降。结论：MLI患者梗死急性期、慢性期及梗死之前均出现了脑血管功能的异常，前两期下降更明显。

THE CHANGES OF CEREBROVASCULAR FUNCTION IN THE PATIENTS WITH MULTIPLE LACUNAR INFARCTION

Objective:To investigate the changes of cerebrovascular function in the patients with multiple lacunar infarct(MLI)at different stage.Methods:200 cases of MLI were divided into acute MLI(AMLI) and chronic MLI(CMLI) group according to the onset time.The patients with cerebrovascular disease risk factors(CVDRF)60 cases,but without MLI were chosen. Three groups were well matched in age ,sex and previous history of disease. The normal control (NC)group was 60 cases. Cerebrovascular function wase evaluated by cerebral vessel hemodynamic indexes(CVDI).Results:Compared with NC,the cerebral circulation was impaired remarkbly in CVDRF, AMLI and CMLI. Compared with AMLI,cerebrovascular function in CMLI was improved to a certain extent In AMLI, CMLI and CVDRF,cebrovascular elasticitys and autoregulations were deteriorated.Conclusions:Cerebrovascular function abnormality exists in both MLI and in CVDRF,and the former is more obvious.