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血管内皮生长因子及其受体在食管癌中的表达和临床意义
引用本文:王海东,王明荣,景涛,杨康,杨军民.血管内皮生长因子及其受体在食管癌中的表达和临床意义[J].中国现代医学杂志,2000,10(10):19-20.
作者姓名:王海东  王明荣  景涛  杨康  杨军民
作者单位:第三军医大学附属西南医院胸心血管外科,重庆,400038
摘    要:为探讨食管癌血管内皮生长因子(VEGF)及其受体(Flt、KDR)、血管生成与食管癌临床病理特点的关系,采用免疫组织化学技术,检测了50例人食管癌组织VEGF、Flt、KDR蛋白表达和微血管密度(MVD)。分析VEGF、Flt、KDR和MVD及其与食管癌组织学分型、浸润深度、生长方式、淋巴结转移和预后的关系。结果显示:VEGF及Flt、KDR阳性者MVD值显著高于阴性者,VEGF、Flt、KDR及MVD与食管癌浸润深度、淋巴结转移密切相关,并最终决定患者的预后。而与组织学分型、生长方式无关。因此认为:VEGF、Flt、KDR与食管癌的血管生成密切相关,对其生长和浸润转移起促进作用,VEGF、Flt、KDR可以作为反映食管癌生物学行为的指标之一。

关 键 词:食管癌  血管生成  受体  表达

THE CLINICAL SIGNIFICANCE AND EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND IT'S RECEPTOR IN ESOPHAGEAL CARCINOMA
Wang Haidong,Wang Mingrong,Jing Tao,Yang Kang,Yang Junmin.THE CLINICAL SIGNIFICANCE AND EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND IT'S RECEPTOR IN ESOPHAGEAL CARCINOMA[J].China Journal of Modern Medicine,2000,10(10):19-20.
Authors:Wang Haidong  Wang Mingrong  Jing Tao  Yang Kang  Yang Junmin
Abstract:To investigate the clinical significance and expression of vascular endothelial growth factor and it's receptor in esophageal carcinoma. Angiogenesis was assessed by the microvessel density (MVD), and protein expression of vascular endothelial growth factor (VEGF), fms-like tyrosine kinase (Flt), kinase insert domain-containing receptor (KDR) using immunohistochemical staining. Paraffin-embedded specimens from 50 patients with esophageal cancer who undergone mastectomy from 1994 to 1995 were studied. VEGF, Flt KDP and MVD expression were analyzed together with their relation to histological type, depth of invasion, growth pattern, lymph node metastasis and distant metastasis. The results show MVD was significantly higher in esophageal carcinoma VEGF, Flt, KDP-positive than in negative group ( P <0.01). The protein expression of VEGF, Flt, KDR, MVD positively correlated with depth of invasion ( P <0.05), lymph node metastasis ( P <0.01), and prognosis. But their relation to the histological types and growth pattern of esophageal carcinoma was not significant. So we concluded that VEGF, Flt, KDR and MVD is highly related to angiogenesis and promotes growth, invasion and metastasis of esophageal carcinoma. The expression of VEGF, Flt, KDR and MVD is one of the predictors for the biological behavior of esophageal carcinoma.
Keywords:Esophageal Carcinoma  Angiogenesis  Clinical Significance
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