| 血浆及乙状结肠粘膜中CCK,SS的含量与肠易激综合征的关系 |
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| 引用本文： | 杨云生,张振书.血浆及乙状结肠粘膜中CCK,SS的含量与肠易激综合征的关系[J].中国现代医学杂志,1997,7(5):12-14. |
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| 作者姓名： | 杨云生 张振书 |
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| 作者单位： | 西安第四军医大学西京医院全军消化病研究所，广州第一军医大学南方医院全军消化内科研究所，广州第一军医大学南方医院全军消化内科研究所，广州第一军医大学南方医院全军消化内科研究所，广州第一军医大学南方医院全军消化内科研究所 710032 |
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| 摘 要： | 采用放射免疫分析法检测24例正常人及26例肠易激综合征(IBS)患者血浆及乙状结肠粘膜中胆囊收缩素(CCK)和生长抑素(SS)的含量,探讨此两种激素在IBS中的可能作用及临床意义。结果:IBS组血浆中CCK、SS的含量明显升高(P<0.05);乙状结肠粘膜中CCK的含量两组无明显差别(P>0.2);SS的含量痛秘型IBS(腹痛便秘为主)显著高于痛泻型IBS(腹痛腹泻为主)(P<0.05),痛泻型IBS显著高于正常人(P<0.05)。结果提示CCK和SS在IBS的疾病过程中可能有一定作用,建议在临床实验诊断中验证它们作为IBS诊断标志的可能性。
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| 关 键 词： | 胆囊收缩素 生长抑制素 肠易激综合征 |
CHOLECYSTOKININ AND SOMATOSTATIN IN PLASMA AND SIGMOID MUCOSA IN IRRITABLE BOWEL SYNDROME |
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| Yang Yunsheng.Zhang Zhengshu .Song Yugang.et al.CHOLECYSTOKININ AND SOMATOSTATIN IN PLASMA AND SIGMOID MUCOSA IN IRRITABLE BOWEL SYNDROME[J].China Journal of Modern Medicine,1997,7(5):12-14. |
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| Authors: | Yang YunshengZhang Zhengshu Song Yugang |
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| Institution: | Yang Yunsheng.Zhang Zhengshu .Song Yugang.et al.
Institute of Digestive Diseases .Xijing Hospital. Fourth Medical University of PLA.Xian 710032 .P. R. China
Institute of Digestive Diseases,Nanfang Hospital First Medical University of PLA,Guangzhou,Guangdong 510000.P. R. China |
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| Abstract: | The aim of this study is to investigate the possible roles and clinical significance of Cholecystokinin (CCK) and somatostatin (SS) in Irritable Bowel Syndrome (IBS). The CCK and SS in plasma and sigmoid mucosa were measured by radioimmunoassay in the control group (n=24)and the IBS group(n=26). The CCK and SS levels in plasma significantly increased in the IBS group( P 0. 02). The SS level in sigmoid mucosa in the IBS group with constipation as the predominant symptom was significantly higher than that in the IBS group with diarrhea as the predominant symptom ( P<0. 05).and the SS level in the IBS group with diarrhea was higher than that in the control group ( P <0. 05 ). The results indicate that CCK and SS may play a role in the IBS process,and may be useful in the clinical diagnosis of IBS. |
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| Keywords: | Cholecystokinin Somatostatin Irritable Bowel Syndrome |
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